Unfavorable Prognostic Factors in JMML
| Feature . | Study (reference) . | Feature . | Study (reference) . |
|---|---|---|---|
| Age (mo) | HBF level | ||
| >48 | Niemeyer19 | Increased | Castro15 |
| >24 | Castro,15 Passmore20 | >15% | Niemeyer19 |
| >12 | Aricò,30 Pui50 | >10% | Owen,29 Passmore20 |
| >6 | Owen29 | Thrombocytopenia (×109/L) | |
| Male sex | Owen29 | <100 | Castro15 |
| <50 | Aricò30 | ||
| Bleeding | Castro,15 Owen29 | <40 | Passmore20 |
| Niemeyer19 | <33 | Niemeyer19 | |
| Hepatomegaly (>3 cm) | Castro15 | Blasts in peripheral blood | |
| ≥2 × 109/L | Castro15 | ||
| Hb level (<10 g/dL) | Niemeyer19 | >4% | Niemeyer19 |
| Reticulocytes (<10%) | Niemeyer19 | Normoblasts in peripheral blood (>1 × 109/L) | Castro15 |
| FPC score (≥2)* | Passmore20 | Blasts in the BM myeloid compartment (>5%) | Niemeyer19 |
| Feature . | Study (reference) . | Feature . | Study (reference) . |
|---|---|---|---|
| Age (mo) | HBF level | ||
| >48 | Niemeyer19 | Increased | Castro15 |
| >24 | Castro,15 Passmore20 | >15% | Niemeyer19 |
| >12 | Aricò,30 Pui50 | >10% | Owen,29 Passmore20 |
| >6 | Owen29 | Thrombocytopenia (×109/L) | |
| Male sex | Owen29 | <100 | Castro15 |
| <50 | Aricò30 | ||
| Bleeding | Castro,15 Owen29 | <40 | Passmore20 |
| Niemeyer19 | <33 | Niemeyer19 | |
| Hepatomegaly (>3 cm) | Castro15 | Blasts in peripheral blood | |
| ≥2 × 109/L | Castro15 | ||
| Hb level (<10 g/dL) | Niemeyer19 | >4% | Niemeyer19 |
| Reticulocytes (<10%) | Niemeyer19 | Normoblasts in peripheral blood (>1 × 109/L) | Castro15 |
| FPC score (≥2)* | Passmore20 | Blasts in the BM myeloid compartment (>5%) | Niemeyer19 |
Relevant in all cases of childhood MDS, including JMML.