Statistical Analysis of Engraftment Parameters in Newborn and Adult Mice
| Effect(s) . | Newborns . | Adults . | ||
|---|---|---|---|---|
| . | F (df) . | P . | F (df) . | P . |
| Cell dose | 9.8 (2) | .0005 | 27.0 (1) | .0001 |
| Radiation | 105.9 (1) | .0001 | 55.4 (1) | .0001 |
| Cell dose × radiation | 6.5 (2) | .004 | 9.7 (3) | .004 |
| Genotype | 9.9 (1) | .004 | — | — |
| Genotype × radiation | 11.7 (1) | .002 | — | — |
| Genotype × cell dose × radiation | — | — | 13.0 (3) | .0001 |
| Effect(s) . | Newborns . | Adults . | ||
|---|---|---|---|---|
| . | F (df) . | P . | F (df) . | P . |
| Cell dose | 9.8 (2) | .0005 | 27.0 (1) | .0001 |
| Radiation | 105.9 (1) | .0001 | 55.4 (1) | .0001 |
| Cell dose × radiation | 6.5 (2) | .004 | 9.7 (3) | .004 |
| Genotype | 9.9 (1) | .004 | — | — |
| Genotype × radiation | 11.7 (1) | .002 | — | — |
| Genotype × cell dose × radiation | — | — | 13.0 (3) | .0001 |
Statistical analysis (analysis of variance) of various engraftment parameters were modeled as described in Materials and Methods. Values are only provided for significant effects. The results indicate that the extent of engraftment is affected by cell dose and by the amount of pretransplant radiation. In addition, engraftment is significantly reduced in ASMKO mice as compared with normal mice (see Fig 1 and text for details). Dashes indicate effects that were not significant.
Abbreviation: df, degrees of freedom.