LGL Cell Line Tumorigenicity in SCID Mice
| Cell Line . | IL-2 Dependent (+ or −) . | Cells Injected (×10−7) . | Tumor Growth/No. of Mice . | Survival Time (mo) . | Organ Involvement . | ||||
|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | LN . | Lung . | Spleen* . | PB . | Liver . |
| F8 | − | 10 | 2/2 | 2.5 | ++ | ++ | + | ++ | + |
| F8 | − | 5 | 2/2 | 2 | ++ | ++ | + | ++ | + |
| F8 | − | 2 | 1/1 | 2.5 | ++ | ++ | + | ND | + |
| F8 | − | 1 | 1/1 | 2 | ++ | ++ | + | ++ | +/− |
| f197 | + | 10 | 1/4 | >6 | + | + | − | + | − |
| m388 | + | 10 | 0/4 | >6 | − | − | − | − | − |
| Cell Line . | IL-2 Dependent (+ or −) . | Cells Injected (×10−7) . | Tumor Growth/No. of Mice . | Survival Time (mo) . | Organ Involvement . | ||||
|---|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | LN . | Lung . | Spleen* . | PB . | Liver . |
| F8 | − | 10 | 2/2 | 2.5 | ++ | ++ | + | ++ | + |
| F8 | − | 5 | 2/2 | 2 | ++ | ++ | + | ++ | + |
| F8 | − | 2 | 1/1 | 2.5 | ++ | ++ | + | ND | + |
| F8 | − | 1 | 1/1 | 2 | ++ | ++ | + | ++ | +/− |
| f197 | + | 10 | 1/4 | >6 | + | + | − | + | − |
| m388 | + | 10 | 0/4 | >6 | − | − | − | − | − |
Abbreviations: ND, not determined; LN, lymph node; PB, peripheral blood (LGL lymphocytosis); ++, marked infiltration; +, slight infiltration.
Structural integrity compromised.