Presenting Features of Children With BL According to Myeloid Antigen Expression
| Variable . | Category . | My+ BL (N = 217) . | My− BL (N = 1,113) . | P Value* . | ||
|---|---|---|---|---|---|---|
| . | . | No. . | (%) . | No. . | (%) . | . |
| Age (yr) | <1 | 3 | (1.4) | 48 | (4.3) | .12 |
| 1-9 | 169 | (77.9) | 845 | (75.9) | ||
| ≥10 | 45 | (20.7) | 220 | (19.8) | ||
| WBC (×109/L) | 1-19 | 149 | (68.7) | 647 | (58.1) | .006 |
| 20-49 | 24 | (11.1) | 208 | (18.7) | ||
| ≥50 | 44 | (20.3) | 258 | (23.2) | ||
| Sex | Male | 123 | (56.7) | 616 | (55.3) | .72 |
| Female | 94 | (43.3) | 497 | (44.7) | ||
| Race | White | 166 | (76.5) | 836 | (75.1) | .83 |
| Black | 13 | (6.0) | 79 | (7.1) | ||
| Other | 38 | (17.5) | 198 | (17.8) | ||
| Down syndrome | Yes | 3 | (1.4) | 25 | (2.2) | .58 |
| No | 214 | (98.6) | 1,087 | (97.8) | ||
| Liver | Normal | 115 | (53.0) | 504 | (45.3) | .12 |
| Mod. enlarged† | 94 | (43.3) | 562 | (50.5) | ||
| Markedly enlarged | 8 | (3.7) | 46 | (4.1) | ||
| Spleen | Normal | 123 | (56.7) | 476 | (42.8) | .0002 |
| Mod. enlarged | 88 | (40.6) | 551 | (49.5) | ||
| Markedly enlarged | 6 | (2.8) | 86 | (7.7) | ||
| Lymph nodes | Normal | 138 | (63.6) | 572 | (51.4) | .004 |
| Mod. enlarged | 72 | (33.2) | 490 | (44.0) | ||
| Markedly enlarged | 7 | (3.2) | 51 | (4.6) | ||
| Mediastinal mass | Absent | 215 | (99.1) | 1,076 | (96.8) | .16 |
| Small | 2 | (0.9) | 30 | (2.7) | ||
| Large | 0 | (0.0) | 6 | (0.5) | ||
| Hemoglobin (g/dL) | 1-7.9 | 133 | (61.3) | 656 | (59.3) | .86 |
| 8.0.-10.9 | 65 | (30.0) | 346 | (31.3) | ||
| ≥11.0 | 19 | (8.8) | 104 | (9.4) | ||
| Platelets (×109/L) | 1-49 | 96 | (44.2) | 590 | (53.0) | .01 |
| 50-149 | 66 | (30.4) | 331 | (29.7) | ||
| ≥150 | 55 | (25.4) | 192 | (17.3) | ||
| CNS disease at diagnosis | Yes | 3 | (1.4) | 27 | (2.4) | .35 |
| No | 212 | (98.6) | 1,081 | (97.6) | ||
| NCI risk category | Standard | 138 | (64.2) | 657 | (59.9) | .27 |
| Poor | 79 | (35.8) | 456 | (40.1) | ||
| Karyotypic features | ||||||
| Number | Diploid (46) | 31 | (43.7) | 93 | (24.1) | .003 |
| Hypodiploid (<46) | 3 | (4.2) | 30 | (7.8) | ||
| Pseudodiploid (46) | 20 | (28.2) | 95 | (24.6) | ||
| Hyperdiploid (47-50) | 8 | (11.3) | 56 | (14.5) | ||
| Hyperdiploid (>50) | 9 | (12.7) | 112 | (29.0) | ||
| Aberrations | Normal | 31 | (43.7) | 93 | (24.1) | .001 |
| Abnormal | 40 | (53.6) | 293 | (75.9) | ||
| Translocations | t(4; 11) present | 0 | (0.0) | 13 | (3.4) | .12 |
| t(4; 11) absent | 71 | (100.0) | 373 | (96.6) | ||
| t(9; 22) present | 3 | (4.2) | 10 | (2.6) | .45 | |
| t(9; 22) absent | 68 | (95.8) | 376 | (97.4) | ||
| Variable . | Category . | My+ BL (N = 217) . | My− BL (N = 1,113) . | P Value* . | ||
|---|---|---|---|---|---|---|
| . | . | No. . | (%) . | No. . | (%) . | . |
| Age (yr) | <1 | 3 | (1.4) | 48 | (4.3) | .12 |
| 1-9 | 169 | (77.9) | 845 | (75.9) | ||
| ≥10 | 45 | (20.7) | 220 | (19.8) | ||
| WBC (×109/L) | 1-19 | 149 | (68.7) | 647 | (58.1) | .006 |
| 20-49 | 24 | (11.1) | 208 | (18.7) | ||
| ≥50 | 44 | (20.3) | 258 | (23.2) | ||
| Sex | Male | 123 | (56.7) | 616 | (55.3) | .72 |
| Female | 94 | (43.3) | 497 | (44.7) | ||
| Race | White | 166 | (76.5) | 836 | (75.1) | .83 |
| Black | 13 | (6.0) | 79 | (7.1) | ||
| Other | 38 | (17.5) | 198 | (17.8) | ||
| Down syndrome | Yes | 3 | (1.4) | 25 | (2.2) | .58 |
| No | 214 | (98.6) | 1,087 | (97.8) | ||
| Liver | Normal | 115 | (53.0) | 504 | (45.3) | .12 |
| Mod. enlarged† | 94 | (43.3) | 562 | (50.5) | ||
| Markedly enlarged | 8 | (3.7) | 46 | (4.1) | ||
| Spleen | Normal | 123 | (56.7) | 476 | (42.8) | .0002 |
| Mod. enlarged | 88 | (40.6) | 551 | (49.5) | ||
| Markedly enlarged | 6 | (2.8) | 86 | (7.7) | ||
| Lymph nodes | Normal | 138 | (63.6) | 572 | (51.4) | .004 |
| Mod. enlarged | 72 | (33.2) | 490 | (44.0) | ||
| Markedly enlarged | 7 | (3.2) | 51 | (4.6) | ||
| Mediastinal mass | Absent | 215 | (99.1) | 1,076 | (96.8) | .16 |
| Small | 2 | (0.9) | 30 | (2.7) | ||
| Large | 0 | (0.0) | 6 | (0.5) | ||
| Hemoglobin (g/dL) | 1-7.9 | 133 | (61.3) | 656 | (59.3) | .86 |
| 8.0.-10.9 | 65 | (30.0) | 346 | (31.3) | ||
| ≥11.0 | 19 | (8.8) | 104 | (9.4) | ||
| Platelets (×109/L) | 1-49 | 96 | (44.2) | 590 | (53.0) | .01 |
| 50-149 | 66 | (30.4) | 331 | (29.7) | ||
| ≥150 | 55 | (25.4) | 192 | (17.3) | ||
| CNS disease at diagnosis | Yes | 3 | (1.4) | 27 | (2.4) | .35 |
| No | 212 | (98.6) | 1,081 | (97.6) | ||
| NCI risk category | Standard | 138 | (64.2) | 657 | (59.9) | .27 |
| Poor | 79 | (35.8) | 456 | (40.1) | ||
| Karyotypic features | ||||||
| Number | Diploid (46) | 31 | (43.7) | 93 | (24.1) | .003 |
| Hypodiploid (<46) | 3 | (4.2) | 30 | (7.8) | ||
| Pseudodiploid (46) | 20 | (28.2) | 95 | (24.6) | ||
| Hyperdiploid (47-50) | 8 | (11.3) | 56 | (14.5) | ||
| Hyperdiploid (>50) | 9 | (12.7) | 112 | (29.0) | ||
| Aberrations | Normal | 31 | (43.7) | 93 | (24.1) | .001 |
| Abnormal | 40 | (53.6) | 293 | (75.9) | ||
| Translocations | t(4; 11) present | 0 | (0.0) | 13 | (3.4) | .12 |
| t(4; 11) absent | 71 | (100.0) | 373 | (96.6) | ||
| t(9; 22) present | 3 | (4.2) | 10 | (2.6) | .45 | |
| t(9; 22) absent | 68 | (95.8) | 376 | (97.4) | ||