Detection of Ferritin in Serum and Peripheral Blood Cells Using Monoclonal Antibodies Specific for the H and L Subunit in Normal and Affected Individuals of Family 1 and 2
| Subjects . | Serum Ferritin (μg/L)* . | Mononuclear Cell Ferritin (fg/cell) . | Red Cell Ferritin (ag/cell) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | H-Type . | L-Type . | % Glycosylation . | H-Type . | L-Type . | L/H Ratio . | H-Type . | L-Type . | L/H Ratio . |
| Normal subjects (n = 5) | <30 | 133 | 60 | 16 | 8 | 0.5 | 18 | 7 | 0.4 |
| (45-169) | (50-66) | (10-22) | (7-15) | (0.4-0.9) | (12-32) | (5-8) | (0.2-0.5) | ||
| Affected individuals of family 1 (n = 4) | <30 | 1,385 | 42 | 8 | 106 | 16.5 | 22 | 114 | 5.3 |
| (1,320-1,890) | (36-45) | (4-12) | (87-119) | (8.9-21.8) | (16-36) | (88-195) | (5.1-5.5) | ||
| Affected individuals of family 2 (n = 3) | < 30 | 556 | 40 | 12 | 44 | 3.6 | ND | ND | ND |
| (470-635) | (31-55) | (11-14) | (40-58) | (3.1-4.8) | |||||
| Subjects . | Serum Ferritin (μg/L)* . | Mononuclear Cell Ferritin (fg/cell) . | Red Cell Ferritin (ag/cell) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | H-Type . | L-Type . | % Glycosylation . | H-Type . | L-Type . | L/H Ratio . | H-Type . | L-Type . | L/H Ratio . |
| Normal subjects (n = 5) | <30 | 133 | 60 | 16 | 8 | 0.5 | 18 | 7 | 0.4 |
| (45-169) | (50-66) | (10-22) | (7-15) | (0.4-0.9) | (12-32) | (5-8) | (0.2-0.5) | ||
| Affected individuals of family 1 (n = 4) | <30 | 1,385 | 42 | 8 | 106 | 16.5 | 22 | 114 | 5.3 |
| (1,320-1,890) | (36-45) | (4-12) | (87-119) | (8.9-21.8) | (16-36) | (88-195) | (5.1-5.5) | ||
| Affected individuals of family 2 (n = 3) | < 30 | 556 | 40 | 12 | 44 | 3.6 | ND | ND | ND |
| (470-635) | (31-55) | (11-14) | (40-58) | (3.1-4.8) | |||||
Abbreviation: ND, not done.
Data are median values and range.