11q23 Partner Chromosome Breakpoints and Fusion Transcripts in ALL
| Chromosome Breakpoint . | Gene Involved . | Fusion Transcript . | Comments . |
|---|---|---|---|
| 1p32 | AF1p | AF1p-MLL | Normally expressed as 4.4 kb transcript in various tissues |
| No known similarity with other genes known to fuse withMLL, but 88% homology with eps15 (refs 133, 134) | |||
| 4q21 | AF4 (FEL, MLLT2) | AF4-MLL | Expressed as two 12-kb and 10.5-kb transcripts in various tissues |
| Encodes protein of 140 kD with putative nuclear targeting sequence and consensus sequence for ATP/GTP binding | |||
| Proline/serine-rich protein | |||
| Most common 11q23 fusion gene (refs 133, 134) | |||
| 10p12-14 | AF10 | AF10-MLL | 5.5-kb mRNA encoding for protein of 1,027 amino acids |
| Contains zinc-finger motif near N-terminus and leucine-zipper motif near C-terminus | |||
| High degree of similarity with AF17 | |||
| IL-2 gene maps to breakpoint region (refs 133, 134) | |||
| 19p13 | ENL (MLLT1, LTG19) | MLL-ENL | 4.7-kb mRNA encoding for protein of 559 amino acids |
| Contains putative nuclear targeting sequence and consensus sequence for ATP/GTP binding | |||
| Proline/serine-rich protein | |||
| 56% identical with AF9 (refs 133, 134) |
| Chromosome Breakpoint . | Gene Involved . | Fusion Transcript . | Comments . |
|---|---|---|---|
| 1p32 | AF1p | AF1p-MLL | Normally expressed as 4.4 kb transcript in various tissues |
| No known similarity with other genes known to fuse withMLL, but 88% homology with eps15 (refs 133, 134) | |||
| 4q21 | AF4 (FEL, MLLT2) | AF4-MLL | Expressed as two 12-kb and 10.5-kb transcripts in various tissues |
| Encodes protein of 140 kD with putative nuclear targeting sequence and consensus sequence for ATP/GTP binding | |||
| Proline/serine-rich protein | |||
| Most common 11q23 fusion gene (refs 133, 134) | |||
| 10p12-14 | AF10 | AF10-MLL | 5.5-kb mRNA encoding for protein of 1,027 amino acids |
| Contains zinc-finger motif near N-terminus and leucine-zipper motif near C-terminus | |||
| High degree of similarity with AF17 | |||
| IL-2 gene maps to breakpoint region (refs 133, 134) | |||
| 19p13 | ENL (MLLT1, LTG19) | MLL-ENL | 4.7-kb mRNA encoding for protein of 559 amino acids |
| Contains putative nuclear targeting sequence and consensus sequence for ATP/GTP binding | |||
| Proline/serine-rich protein | |||
| 56% identical with AF9 (refs 133, 134) |