Biological Parameters of the Two Groups Studied
| . | CAD-Free (n = 137) . | CAD (n = 278) . |
|---|---|---|
| Age (yr) | 59.3 ± 11.8 | 61.1 ± 8.9 |
| Male/female | 79/58 | 243/35 |
| Menopausal women (%) | 83 | 97 |
| BMI (kg/m2) | 24.9 ± 3.2 | 26.3 ± 3-150 |
| Smoking (%) | 42.5 | 70-151 |
| Hypertension (%) | 29.8 | 57.4-151 |
| Total cholesterol (mmol/L) | 5.6 ± 1.1 | 6.2 ± 1.1-150 |
| LDL cholesterol (mmol/L) | 3.7 ± 0.9 | 4.2 ± 1-150 |
| HDL cholesterol (mmol/L) | 1.5 ± 0.4 | 1.2 ± 0.3-150 |
| Triglycerides (mmol/L) | 1.5 ± 0.7 | 2.1 ± 1.7-150 |
| Ascertained previous MI (%) | — | 66 |
| GM fasting tHcy (μmol/L) | 14.2 | 15.7-150 |
| GM PML tHcy increase (μmol/L) | 23.5 | 24.1 |
| Hyperhomocysteinemia-152(%) | 28.8 | 41-151 |
| GM folate (nmol/L) | 12.4 | 11.3 |
| GM vitamin B12 (ng/L) | 443 | 411 |
| . | CAD-Free (n = 137) . | CAD (n = 278) . |
|---|---|---|
| Age (yr) | 59.3 ± 11.8 | 61.1 ± 8.9 |
| Male/female | 79/58 | 243/35 |
| Menopausal women (%) | 83 | 97 |
| BMI (kg/m2) | 24.9 ± 3.2 | 26.3 ± 3-150 |
| Smoking (%) | 42.5 | 70-151 |
| Hypertension (%) | 29.8 | 57.4-151 |
| Total cholesterol (mmol/L) | 5.6 ± 1.1 | 6.2 ± 1.1-150 |
| LDL cholesterol (mmol/L) | 3.7 ± 0.9 | 4.2 ± 1-150 |
| HDL cholesterol (mmol/L) | 1.5 ± 0.4 | 1.2 ± 0.3-150 |
| Triglycerides (mmol/L) | 1.5 ± 0.7 | 2.1 ± 1.7-150 |
| Ascertained previous MI (%) | — | 66 |
| GM fasting tHcy (μmol/L) | 14.2 | 15.7-150 |
| GM PML tHcy increase (μmol/L) | 23.5 | 24.1 |
| Hyperhomocysteinemia-152(%) | 28.8 | 41-151 |
| GM folate (nmol/L) | 12.4 | 11.3 |
| GM vitamin B12 (ng/L) | 443 | 411 |
CAD-free subjects were those with documented normal coronary angiogram (n = 137). CAD subjects were those with angiographically documented coronary artery disease (n = 278).
Abbreviations: GM, geometric mean; tHcy, total homocysteine, adjusted for age and sex; MI, myocardial infarction.
P < .05 by using the t-test (on log-transformed data for skewed variables).
P < .05 by using the χ2 test.
Defined as at least one of the two values in the top fifth of the control distribution (ie, fasting tHcy ≥19 μmol/L and PML tHcy increase ≥31.7 μmol/L).