Plasma Hcy Levels in the Whole Population as a Function of MTHFR Genotype and Folate Levels (Stratification by Folate Values Above and Below the Median)
| MTHFR Genotype . | A/A . | A/V . | V/V . |
|---|---|---|---|
| Fasting tHcy (μmol/L) | 13.9* | 15.2* | 18.4 |
| Folate ≥11.5 nmol/L | 13 | 14.1 | 12.7 |
| Folate <11.5 nmol/L | 14.5* | 16.7*,† | 23.1 |
| PML tHcy increase (μmol/L) | 23.6 | 23.6 | 25.5 |
| Folate ≥11.5 nmol/L | 22.9 | 23.5 | 21.4 |
| Folate <11.5 nmol/L | 24.9 | 25.1 | 28.8 |
| MTHFR Genotype . | A/A . | A/V . | V/V . |
|---|---|---|---|
| Fasting tHcy (μmol/L) | 13.9* | 15.2* | 18.4 |
| Folate ≥11.5 nmol/L | 13 | 14.1 | 12.7 |
| Folate <11.5 nmol/L | 14.5* | 16.7*,† | 23.1 |
| PML tHcy increase (μmol/L) | 23.6 | 23.6 | 25.5 |
| Folate ≥11.5 nmol/L | 22.9 | 23.5 | 21.4 |
| Folate <11.5 nmol/L | 24.9 | 25.1 | 28.8 |
tHcy data are expressed as geometric means.
Significantly different from V/V by ANOVA and Tukey's post-hoc multiple comparison of the means of log-transformed data (P < .001).
Significantly different from all the other categories (A/A with low and high folate, A/V and V/V with high folate) after exclusion of the V/V with low folate group from the analysis (ANOVA and Tukey's post-hoc multiple comparison of the means of log-transformed data;P < .001).