Biological Parameters in CAD Subjects With Different MTHFR Genotypes
| MTHFR Genotype . | A/A . | A/V . | V/V . |
|---|---|---|---|
| Age (yr) | 60.2 ± 9.6 | 61.2 ± 8.4 | 62.7 ± 9.4 |
| BMI (kg/m2) | 26.2 ± 3.1 | 26.4 ± 2.9 | 26.1 ± 3.3 |
| Total cholesterol (mmol/L) | 6.19 ± 1.2 | 6.19 ± 1.1 | 5.99 ± 1.0 |
| LDL cholesterol (mmol/L) | 4.28 ± 1.1 | 4.18 ± 1.0 | 4.0 ± 0.9 |
| HDL cholesterol (mmol/L) | 1.27 ± 0.4 | 1.24 ± 0.3 | 1.29 ± 0.4 |
| Triglycerides (mmol/L) | 2.02 ± 1.5 | 2.26 ± 2.0 | 1.97 ± 1.2 |
| Hypertension (%) | 66 | 503-150 | 64 |
| Smoking (%) | 64 | 72 | 75 |
| Ascertained previous MI (%) | 65 | 64 | 72 |
| GM fasting tHcy (μmol/L) | 14†‡ | 15.63-151 | 21.1 |
| GM PML tHcy increase (μmol/L) | 23.8 | 23.8 | 25.6 |
| GM folate (nmol/L) | 11.7 | 11.3 | 10.3 |
| MTHFR Genotype . | A/A . | A/V . | V/V . |
|---|---|---|---|
| Age (yr) | 60.2 ± 9.6 | 61.2 ± 8.4 | 62.7 ± 9.4 |
| BMI (kg/m2) | 26.2 ± 3.1 | 26.4 ± 2.9 | 26.1 ± 3.3 |
| Total cholesterol (mmol/L) | 6.19 ± 1.2 | 6.19 ± 1.1 | 5.99 ± 1.0 |
| LDL cholesterol (mmol/L) | 4.28 ± 1.1 | 4.18 ± 1.0 | 4.0 ± 0.9 |
| HDL cholesterol (mmol/L) | 1.27 ± 0.4 | 1.24 ± 0.3 | 1.29 ± 0.4 |
| Triglycerides (mmol/L) | 2.02 ± 1.5 | 2.26 ± 2.0 | 1.97 ± 1.2 |
| Hypertension (%) | 66 | 503-150 | 64 |
| Smoking (%) | 64 | 72 | 75 |
| Ascertained previous MI (%) | 65 | 64 | 72 |
| GM fasting tHcy (μmol/L) | 14†‡ | 15.63-151 | 21.1 |
| GM PML tHcy increase (μmol/L) | 23.8 | 23.8 | 25.6 |
| GM folate (nmol/L) | 11.7 | 11.3 | 10.3 |
Abbreviation: GM, expressed as geometric means.
Significantly different from V/V and A/A by χ2(df = 2, P = .04).
Significantly different from V/V by ANOVA and Tukey's post-hoc multiple comparison of the means of log-transformed data (P < .001).
Significantly different from A/V by ANOVA and Tukey's post-hoc multiple comparison of the means of log-transformed data (P < .05).