Characteristics of the Patients Before and During IFN-α Therapy
| Case . | Sex, Age at Diagnosis . | Date of Diagnosis (d/mo/yr) . | Date of Splenectomy (d/mo/yr) . | Previous Therapy Before IFN-α . | Date of Start of IFN-α (d/mo/yr) . | Laboratory Values Before Start of IFN-α . | Laboratory Values During IFN-α . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hb g/dL . | WBC Cells/μL . | % HCL Cells . | Thrombocytes . | Day of IFN-α . | Hb g/dL . | WBC Cells/μL . | % HCL Cells . | Thrombocytes . | ||||||
| A | M, 39 yr | 5/9/91 | 20/9/91 | None | 22/4/92 | 12.0 | 33,000 | 86 | 117 | +6 | 12.0 | 31,100 | 90 | 125 |
| +29 | 11.3 | 18,400 | 78 | 161 | ||||||||||
| +236 | 13.0 | 4,100 | 12 | 151 | ||||||||||
| +736 | 15.6 | 6,100 | 2 | 274 | ||||||||||
| +1,183 | 14.3 | 8,400 | <0.1 | 320 | ||||||||||
| B | M, 46 yr | 10/7/92 | 5/8/92 | None | 22/2/93 | 13.0 | 98,400 | 94 | 100 | +1,242 | 16.2 | 5,600 | 2 | 312 |
| C | M, 34 yr | 2/9/86 | 26/5/87 | None | 16/5/90 | 11.5 | 3,400 | 4 | 370 | +742 | 16.2 | 5,000 | <0.1 | 347 |
| D | M, 26 yr | 13/2/91 | 19/3/91 | None | 20/4/93 | 13.0 | 53,000 | 74 | 110 | +904 | 15.6 | 4,500 | 3 | 230 |
| E | M, 39 yr | 9/10/92 | 9/10/92 | None | 16/3/95 | 8.6 | 5,200 | 14 | 104 | +315 | 14.7 | 4,300 | <0.1 | 252 |
| F | M, 42 yr | 1/5/88 | 14/7/88 | None | 23/4/91 | 12.3 | 2,600 | 19 | 43 | +204 | 13.8 | 3,900 | 6 | 268 |
| +1,646 | 14.7 | 8,300 | <0.1 | 337 | ||||||||||
| G | M, 50 yr | 1/2/82 | 9/3/82 | Chlorambucil 6 mo (1983) IFN-α 1986-1987 | 2nd period: 24/8/93 | 12.5 | 10,400 | 21 | 310 | +463 +1,050 | 13.4 13.0 | 7,400 8,200 | 1 1 | 250 268 |
| Case . | Sex, Age at Diagnosis . | Date of Diagnosis (d/mo/yr) . | Date of Splenectomy (d/mo/yr) . | Previous Therapy Before IFN-α . | Date of Start of IFN-α (d/mo/yr) . | Laboratory Values Before Start of IFN-α . | Laboratory Values During IFN-α . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hb g/dL . | WBC Cells/μL . | % HCL Cells . | Thrombocytes . | Day of IFN-α . | Hb g/dL . | WBC Cells/μL . | % HCL Cells . | Thrombocytes . | ||||||
| A | M, 39 yr | 5/9/91 | 20/9/91 | None | 22/4/92 | 12.0 | 33,000 | 86 | 117 | +6 | 12.0 | 31,100 | 90 | 125 |
| +29 | 11.3 | 18,400 | 78 | 161 | ||||||||||
| +236 | 13.0 | 4,100 | 12 | 151 | ||||||||||
| +736 | 15.6 | 6,100 | 2 | 274 | ||||||||||
| +1,183 | 14.3 | 8,400 | <0.1 | 320 | ||||||||||
| B | M, 46 yr | 10/7/92 | 5/8/92 | None | 22/2/93 | 13.0 | 98,400 | 94 | 100 | +1,242 | 16.2 | 5,600 | 2 | 312 |
| C | M, 34 yr | 2/9/86 | 26/5/87 | None | 16/5/90 | 11.5 | 3,400 | 4 | 370 | +742 | 16.2 | 5,000 | <0.1 | 347 |
| D | M, 26 yr | 13/2/91 | 19/3/91 | None | 20/4/93 | 13.0 | 53,000 | 74 | 110 | +904 | 15.6 | 4,500 | 3 | 230 |
| E | M, 39 yr | 9/10/92 | 9/10/92 | None | 16/3/95 | 8.6 | 5,200 | 14 | 104 | +315 | 14.7 | 4,300 | <0.1 | 252 |
| F | M, 42 yr | 1/5/88 | 14/7/88 | None | 23/4/91 | 12.3 | 2,600 | 19 | 43 | +204 | 13.8 | 3,900 | 6 | 268 |
| +1,646 | 14.7 | 8,300 | <0.1 | 337 | ||||||||||
| G | M, 50 yr | 1/2/82 | 9/3/82 | Chlorambucil 6 mo (1983) IFN-α 1986-1987 | 2nd period: 24/8/93 | 12.5 | 10,400 | 21 | 310 | +463 +1,050 | 13.4 13.0 | 7,400 8,200 | 1 1 | 250 268 |
Abbreviations: Hb, hemoglobin; WBC, white blood cell count.