Clinical Characteristics of Patients Infected With HGV or HCV Before BMT and Analysis of Early Liver Dysfunction After BMT
| . | None . | HGV RNA+ . | HCV RNA+ . | HCV and HGV RNA+ . |
|---|---|---|---|---|
| . | (n = 36) . | (n = 12) . | (n = 5) . | (n = 6) . |
| History of transfusion | 15/36 | 12/12 | 5/5 | 6/6 |
| Exposed donors | 10 (0-33) | 82 (3-236) | 112 (49-164) | 84 (12-344) |
| Underlying disease | ||||
| CML | 18 | AL 10 | AL 5 | AL 5 |
| AL | 11 | SAA 1 | CML 1 | |
| MDS | 4 | MM 1 | ||
| SAA | 3 | |||
| Stage at BMT | ||||
| Active disease3-150 | 5/33 (15%) | 1/12 (8%) | 2/5 (40%) | 4/6 (66%) |
| Second BMT | 0 | 1 | 0 | 2 |
| Abnormal ALT before BMT | 4 (11%) | 3 (25%) | 2 (40%) | 5 (83%) |
| Maximum ALT levels in the first 100 days after BMT | 67 (24-2925) | 111 (41-900) | 87 (10-271) | 290 (113-490) |
| Day of maximum ALT | 14 (0-30) | 21 (2-30) | 5 (1-20) | 7 (3-18) |
| Type of early liver dysfunction | ||||
| No liver toxicity | 6 | 3 | 1 | |
| Toxicity | 22 | 5 | 2 | 1 |
| Acute GVHD | 5 | 3 | 1 | 2 |
| VOD (fatal VOD) | 3 (0) | 1 (0) | 1 (0) | 4 (2) |
| . | None . | HGV RNA+ . | HCV RNA+ . | HCV and HGV RNA+ . |
|---|---|---|---|---|
| . | (n = 36) . | (n = 12) . | (n = 5) . | (n = 6) . |
| History of transfusion | 15/36 | 12/12 | 5/5 | 6/6 |
| Exposed donors | 10 (0-33) | 82 (3-236) | 112 (49-164) | 84 (12-344) |
| Underlying disease | ||||
| CML | 18 | AL 10 | AL 5 | AL 5 |
| AL | 11 | SAA 1 | CML 1 | |
| MDS | 4 | MM 1 | ||
| SAA | 3 | |||
| Stage at BMT | ||||
| Active disease3-150 | 5/33 (15%) | 1/12 (8%) | 2/5 (40%) | 4/6 (66%) |
| Second BMT | 0 | 1 | 0 | 2 |
| Abnormal ALT before BMT | 4 (11%) | 3 (25%) | 2 (40%) | 5 (83%) |
| Maximum ALT levels in the first 100 days after BMT | 67 (24-2925) | 111 (41-900) | 87 (10-271) | 290 (113-490) |
| Day of maximum ALT | 14 (0-30) | 21 (2-30) | 5 (1-20) | 7 (3-18) |
| Type of early liver dysfunction | ||||
| No liver toxicity | 6 | 3 | 1 | |
| Toxicity | 22 | 5 | 2 | 1 |
| Acute GVHD | 5 | 3 | 1 | 2 |
| VOD (fatal VOD) | 3 (0) | 1 (0) | 1 (0) | 4 (2) |
Abbreviations: CML, chronic myeloid leukemia; AL, acute leukemia; SAA, severe aplastic anemia; MDS, myelodysplastic syndrome; MM, multiple myeloma; GVHD, graft-versus-host disease; VOD, venoocclusive disease of the liver.
Active disease: patients with acute leukemia or CML transplanted in situation other than remission or first chronic phase.