A Comparison of Hematologic Indices in Outbred 129/BL Swiss and Inbred 129 Mice Bearing Hetero- and Homozygous α1− Null Alleles
| . | A.129/BL Swiss Mixed Background . | ||||
|---|---|---|---|---|---|
| . | Genotype . | Hb g/dL . | MCV fL . | MCH pg . | RDW % . |
| Wild-type (N = 7) | ζα1α2/ζα1α2 | 15.7 (0.5) | 52.3 (0.9) | 17.4 (0.9) | 12.6 (1.6) |
| α1− Heterozygote (N = 5) | ζα1−α2/ζα1α2 | 13.8 (2.0) | 42.2 (7.0) | 14.6 (0.5) | 14.2 (1.4) |
| α1− Homozygote (N = 9) | ζα1−α2/ζα1−α2 | 12.7 (0.4) | 41.6 (2.5) | 13.3 (0.9) | 18.1 (1.4) |
| B.129 Inbred Background | |||||
| Genotype | Hb g/dL | MCV fL | MCH pg | RDW % | |
| . | A.129/BL Swiss Mixed Background . | ||||
|---|---|---|---|---|---|
| . | Genotype . | Hb g/dL . | MCV fL . | MCH pg . | RDW % . |
| Wild-type (N = 7) | ζα1α2/ζα1α2 | 15.7 (0.5) | 52.3 (0.9) | 17.4 (0.9) | 12.6 (1.6) |
| α1− Heterozygote (N = 5) | ζα1−α2/ζα1α2 | 13.8 (2.0) | 42.2 (7.0) | 14.6 (0.5) | 14.2 (1.4) |
| α1− Homozygote (N = 9) | ζα1−α2/ζα1−α2 | 12.7 (0.4) | 41.6 (2.5) | 13.3 (0.9) | 18.1 (1.4) |
| B.129 Inbred Background | |||||
| Genotype | Hb g/dL | MCV fL | MCH pg | RDW % | |
| Wild-type (N = 7) | ζα1α2/ζα1α2 | 16.0 (0.2) | 47.4 (1.0) | 16.5 (0.8) | 13.2 (0.2) (N = 3) |
| α1− Heterozygote (N = 7) | ζα1−α2/ζα1α2 | 15.0 (0.3) | 41.4 (0.8) | 14.0 (0.2) | 18.2 (0.5) (N = 4) |
| α1− Homozygote (N = 7) | ζα1−α2/ζα1−α2 | 7.9 (0.4) | 38.5 (0.5) | 12.2 (0.7) | 33.8 (10.0) |
| Wild-type (N = 7) | ζα1α2/ζα1α2 | 16.0 (0.2) | 47.4 (1.0) | 16.5 (0.8) | 13.2 (0.2) (N = 3) |
| α1− Heterozygote (N = 7) | ζα1−α2/ζα1α2 | 15.0 (0.3) | 41.4 (0.8) | 14.0 (0.2) | 18.2 (0.5) (N = 4) |
| α1− Homozygote (N = 7) | ζα1−α2/ζα1−α2 | 7.9 (0.4) | 38.5 (0.5) | 12.2 (0.7) | 33.8 (10.0) |
Abbreviation: RDW, red cell distribution width.