In Vitro Activities of SANORG 34006
| Compounds . | Anti-Xa Activity . | kd for ATIII (nmol/L) . | TG (extrinsic) IC50 (μg/mL) . | APTT (U/mg) . | |
|---|---|---|---|---|---|
| (U/mg) . | (U/nmol) . | ||||
| Standard heparin | 180 ± 11 | ND | 0.27 ± 0.05 | 180 | |
| SR90107A/ORG 31540 | 850 ± 27 | 1.4 | 48 ± 11 | 0.64 ± 0.02 | 3 ± 3 |
| SANORG 34006 | 1,240 ± 15 | 2.1 | 1.4 ± 0.3 | 0.58 ± 0.01 | 1.1 ± 0.16 |
| Compounds . | Anti-Xa Activity . | kd for ATIII (nmol/L) . | TG (extrinsic) IC50 (μg/mL) . | APTT (U/mg) . | |
|---|---|---|---|---|---|
| (U/mg) . | (U/nmol) . | ||||
| Standard heparin | 180 ± 11 | ND | 0.27 ± 0.05 | 180 | |
| SR90107A/ORG 31540 | 850 ± 27 | 1.4 | 48 ± 11 | 0.64 ± 0.02 | 3 ± 3 |
| SANORG 34006 | 1,240 ± 15 | 2.1 | 1.4 ± 0.3 | 0.58 ± 0.01 | 1.1 ± 0.16 |
Means ± SD (n = 9).
Abbreviation: ND, not determined.