The Effect of Nucleotide Precursors on the Inhibitory Activity of CDD
| dT + CDD . | dT + CDD + dA (10−5 mol/L) . | dT + CDD + dA (10−4 mol/L) . | dT + CDD + dG (10−5 mol/L) . | dT + CDD + dG (10−4 mol/L) . |
|---|---|---|---|---|
| 42% | 43% | 33% | 30% | 15% |
| dT + CDD . | dT + CDD + dA (10−5 mol/L) . | dT + CDD + dA (10−4 mol/L) . | dT + CDD + dG (10−5 mol/L) . | dT + CDD + dG (10−4 mol/L) . |
|---|---|---|---|---|
| 42% | 43% | 33% | 30% | 15% |
Mouse BMC were cultured for 7 days in a GM-CFC agar assay with 10% CM 5637 as stimulator. Thymidine (dT) was added at 10−4 mol/L concentration and rh CDD at 25 ng/plate. Colonies of more than 50 cells were counted, and the values are given as percent of controls. No effect was obtained with dT or CDD alone.