Laboratory Values During Treatment With HU
| Parameters . | Pretreatment Value (n = 29) . | HbF Maximal Response (n = 28) . | Year 1 (n = 28) . | Year 2 (n = 20) . | Year 3 (n = 8) . |
|---|---|---|---|---|---|
| Total hemoglobin (g/dL) | 8.4 ± 1.2 | 8.9 ± 1.1* | 9.0 ± 1.2 | 9.1 ± 0.9 | 9.2 ± 0.6 |
| MCV (fL) | 84.5 ± 10.1 | 101.4 ± 13.4* | 101.6 ± 13.6 | 101.8 ± 15.9 | 102.4 ± 14.8 |
| Neutrophils (×109/L) | 7.2 ± 2.9 | 4.2 ± 2.6* | 4.3 ± 2.9 | 5.2 ± 2.3 | 4.7 ± 2.9 |
| Platelets (×109/L) | 393 ± 170 | 340 ± 114 | 338 ± 117 | 293 ± 175 | 340 ± 109 |
| Reticulocytes (×109/L) | 417 ± 214 | 229 ± 129* | 235 ± 109 | 266 ± 140 | 192 ± 73 |
| HbF (%) | 4.0 ± 3.4 | 17.3 ± 8.5* | 13.9 ± 7.4 | 13.0 ± 9.4 | 22.5 ± 2.8 |
| F reticulocytes (%) | 7.1 ± 3.9 | 21.7 ± 10.7* | 24.6 ± 15.0 | 26.0 ± 16.9 | 32.7 ± 35.1 |
| F cells (%) | 24.4 ± 14.3 | 59.9 ± 19.4* | 57.0 ± 23.2 | 54.2 ± 22.1 | 55.5 ± 27.3 |
| F/F cell (pg) | 4.1 ± 1.3 | 8.7 ± 2.7* | 8.4 ± 2.3 | 6.9 ± 3.3 | 11.8 ± 1.7 |
| Parameters . | Pretreatment Value (n = 29) . | HbF Maximal Response (n = 28) . | Year 1 (n = 28) . | Year 2 (n = 20) . | Year 3 (n = 8) . |
|---|---|---|---|---|---|
| Total hemoglobin (g/dL) | 8.4 ± 1.2 | 8.9 ± 1.1* | 9.0 ± 1.2 | 9.1 ± 0.9 | 9.2 ± 0.6 |
| MCV (fL) | 84.5 ± 10.1 | 101.4 ± 13.4* | 101.6 ± 13.6 | 101.8 ± 15.9 | 102.4 ± 14.8 |
| Neutrophils (×109/L) | 7.2 ± 2.9 | 4.2 ± 2.6* | 4.3 ± 2.9 | 5.2 ± 2.3 | 4.7 ± 2.9 |
| Platelets (×109/L) | 393 ± 170 | 340 ± 114 | 338 ± 117 | 293 ± 175 | 340 ± 109 |
| Reticulocytes (×109/L) | 417 ± 214 | 229 ± 129* | 235 ± 109 | 266 ± 140 | 192 ± 73 |
| HbF (%) | 4.0 ± 3.4 | 17.3 ± 8.5* | 13.9 ± 7.4 | 13.0 ± 9.4 | 22.5 ± 2.8 |
| F reticulocytes (%) | 7.1 ± 3.9 | 21.7 ± 10.7* | 24.6 ± 15.0 | 26.0 ± 16.9 | 32.7 ± 35.1 |
| F cells (%) | 24.4 ± 14.3 | 59.9 ± 19.4* | 57.0 ± 23.2 | 54.2 ± 22.1 | 55.5 ± 27.3 |
| F/F cell (pg) | 4.1 ± 1.3 | 8.7 ± 2.7* | 8.4 ± 2.3 | 6.9 ± 3.3 | 11.8 ± 1.7 |
*P < .05 from Wilcoxon signed test, comparing the pretreatment values with values at HbF maximal response.