Clot Times for Experiments in Normal and Factor XI-Deficient Whole Human Blood, With Controls
| Donor . | Initiator Concentration . | |
|---|---|---|
| 25 pmol/L TF . | 5 pmol/L TF . | |
| XI-deficient | 3.5 min (control, −TF >20.5 min) | 15.7 min (control, −TF >20.8 min) |
| XI-deficient with replacement | 3.7 min (control, −TF >20.3 min) | 9.7 min (control, −TF >20.8 min) |
| Normal | 3.3 min (control, −TF = 12.1 min) | 11.1 min (control, −TF = 18.1 min) |
| Donor . | Initiator Concentration . | |
|---|---|---|
| 25 pmol/L TF . | 5 pmol/L TF . | |
| XI-deficient | 3.5 min (control, −TF >20.5 min) | 15.7 min (control, −TF >20.8 min) |
| XI-deficient with replacement | 3.7 min (control, −TF >20.3 min) | 9.7 min (control, −TF >20.8 min) |
| Normal | 3.3 min (control, −TF = 12.1 min) | 11.1 min (control, −TF = 18.1 min) |
Data are given for each of the experiments described in the text, along with phlebotomy control values (in parentheses) for clotting in the absence of added TF initiator. Where phlebotomy controls exhibited no clotting by the end of the experiment, times are indicated as lower limits (denoted by a greater than symbol). In all experiments, including controls, factor XIIa activity was suppressed by the addition of corn trypsin inhibitor at the level of 48 μg/mL of blood (see the Materials and Methods for brief description of the experiments). For the experiments with 25 pmol/L initiator, the donor was patient C1; in the 5 pmol/L experiments, the donor was patient C2.