Immunophenotypic Characteristics of BMMC in SMCD Patients and Healthy Controls
| CD . | Indolent SMCD N = 10 . | Healthy Controls N = 19 . | P Value . |
|---|---|---|---|
| 2* | 9.87 ± 6.25 | Negative | .0001 |
| 5-24.9 | |||
| 100% | |||
| 9 | 826.30 ± 337.33 | 1,047.4 ± 474.5 | NS |
| 780.0-1,111.7 | 431.6-1692.0 | ||
| 100% | 100% | ||
| 11b | 6.5 | 6.25 ± 0.49 | NS |
| <5-6.5 | <5-6.6 | ||
| 25% | 50% | ||
| 11c | 20.1 ± 5.2 | 11.1 ± 2.2 | NS |
| 12.9-25.5 | <5.0-14.2 | ||
| 100% | 87% | ||
| 13 | 20.9 ± 21.5 | 13.8 ± 17.7 | NS |
| 7.0-56.9 | <5.0-50 | ||
| 100% | 77% | ||
| 18 | 5.8 ± 0.07 | 6.0 ± 0.1 | NS |
| <5-5.9 | <5.0-6.1 | ||
| 40% | 62% | ||
| 22 | 11.9 ± 6.9 | 6.4 ± 1.0 | NS |
| <5-25.5 | <5.0-7.9 | ||
| 78% | 50% | ||
| 25* | 33.8 ± 16.57 | Negative | .0001 |
| 18.1-48.5 | |||
| 100% | |||
| 29 | 15.0 ± 5.3 | 30.6 ± 10.1 | .03 |
| 9.1-21.5 | 18.5-45.4 | ||
| 100 | 100 | ||
| 33 | 58.9 ± 30.3 | 22.5 ± 14.0 | .02 |
| 14.2-102.8 | 7.8-51.7 | ||
| 100% | 100% | ||
| 35* | 44.1 ± 0.14 | Negative | .006 |
| 44-44.2 | |||
| 100% | |||
| 41a* | 7.9 ± 2.66 | Negative | NS |
| <5-11.8 | |||
| 71% | |||
| 42b* | 14.9 | Negative | NS |
| <5-14.9 | |||
| 25% | |||
| 43 | 13.0 ± 10.96 | 26.6 ± 27.9 | NS |
| <5-25.7 | 11.4-83.2 | ||
| 60% | 100% | ||
| 44 | 140.8 ± 56.9 | 167.5 ± 99.6 | NS |
| 59.6-224.6 | 82.1-339.2 | ||
| 100% | 100% | ||
| 45† | 100% | 100% | NS |
| 49d | 17.1 ± 2.6 | 21.2 ± 6.4 | NS |
| <5-26.5 | 16.9-33.9 | ||
| 50% | 100% | ||
| 49e | 7.0 | 7.2 ± 1.7 | NS |
| <5-7.0 | 5.0-9.4 | ||
| 25% | 100% | ||
| 51 | 5.5 | 8.6 ± 3.4 | NS |
| <5-5.5 | 5.6-13.2 | ||
| 20% | 100% | ||
| 54 | 75.6 ± 55.8 | 14.2 ± 4.2 | NS |
| 6.5-134.6 | <5.0-18.7 | ||
| 100% | 75% | ||
| 61 | 11.5 ± 8.4 | 8.3 ± 2.5 | NS |
| <5-17.5 | <5-11.8 | ||
| 28% | 85% | ||
| 71* | Negative | 6.9 ± 1.4 | .004 |
| 5.0-8.3 | |||
| 100% | |||
| 117‡ | 174.1 ± 78.5 | 322.1 ± 192.2 | .008 |
| 93.4-383.7 | 87.8-860.1 | ||
| 100% | 100% | ||
| FceRI | 311.9 ± 273.7 | 428.3 ± 198.2 | NS |
| 41.3-747.5 | 288.1-568.5 | ||
| 100% | 100% |
| CD . | Indolent SMCD N = 10 . | Healthy Controls N = 19 . | P Value . |
|---|---|---|---|
| 2* | 9.87 ± 6.25 | Negative | .0001 |
| 5-24.9 | |||
| 100% | |||
| 9 | 826.30 ± 337.33 | 1,047.4 ± 474.5 | NS |
| 780.0-1,111.7 | 431.6-1692.0 | ||
| 100% | 100% | ||
| 11b | 6.5 | 6.25 ± 0.49 | NS |
| <5-6.5 | <5-6.6 | ||
| 25% | 50% | ||
| 11c | 20.1 ± 5.2 | 11.1 ± 2.2 | NS |
| 12.9-25.5 | <5.0-14.2 | ||
| 100% | 87% | ||
| 13 | 20.9 ± 21.5 | 13.8 ± 17.7 | NS |
| 7.0-56.9 | <5.0-50 | ||
| 100% | 77% | ||
| 18 | 5.8 ± 0.07 | 6.0 ± 0.1 | NS |
| <5-5.9 | <5.0-6.1 | ||
| 40% | 62% | ||
| 22 | 11.9 ± 6.9 | 6.4 ± 1.0 | NS |
| <5-25.5 | <5.0-7.9 | ||
| 78% | 50% | ||
| 25* | 33.8 ± 16.57 | Negative | .0001 |
| 18.1-48.5 | |||
| 100% | |||
| 29 | 15.0 ± 5.3 | 30.6 ± 10.1 | .03 |
| 9.1-21.5 | 18.5-45.4 | ||
| 100 | 100 | ||
| 33 | 58.9 ± 30.3 | 22.5 ± 14.0 | .02 |
| 14.2-102.8 | 7.8-51.7 | ||
| 100% | 100% | ||
| 35* | 44.1 ± 0.14 | Negative | .006 |
| 44-44.2 | |||
| 100% | |||
| 41a* | 7.9 ± 2.66 | Negative | NS |
| <5-11.8 | |||
| 71% | |||
| 42b* | 14.9 | Negative | NS |
| <5-14.9 | |||
| 25% | |||
| 43 | 13.0 ± 10.96 | 26.6 ± 27.9 | NS |
| <5-25.7 | 11.4-83.2 | ||
| 60% | 100% | ||
| 44 | 140.8 ± 56.9 | 167.5 ± 99.6 | NS |
| 59.6-224.6 | 82.1-339.2 | ||
| 100% | 100% | ||
| 45† | 100% | 100% | NS |
| 49d | 17.1 ± 2.6 | 21.2 ± 6.4 | NS |
| <5-26.5 | 16.9-33.9 | ||
| 50% | 100% | ||
| 49e | 7.0 | 7.2 ± 1.7 | NS |
| <5-7.0 | 5.0-9.4 | ||
| 25% | 100% | ||
| 51 | 5.5 | 8.6 ± 3.4 | NS |
| <5-5.5 | 5.6-13.2 | ||
| 20% | 100% | ||
| 54 | 75.6 ± 55.8 | 14.2 ± 4.2 | NS |
| 6.5-134.6 | <5.0-18.7 | ||
| 100% | 75% | ||
| 61 | 11.5 ± 8.4 | 8.3 ± 2.5 | NS |
| <5-17.5 | <5-11.8 | ||
| 28% | 85% | ||
| 71* | Negative | 6.9 ± 1.4 | .004 |
| 5.0-8.3 | |||
| 100% | |||
| 117‡ | 174.1 ± 78.5 | 322.1 ± 192.2 | .008 |
| 93.4-383.7 | 87.8-860.1 | ||
| 100% | 100% | ||
| FceRI | 311.9 ± 273.7 | 428.3 ± 198.2 | NS |
| 41.3-747.5 | 288.1-568.5 | ||
| 100% | 100% |
Results expressed as mean ± SD and range of antigen expression in MESF (units × 103), and percentage of positive cases. P values were calculated for differences in the intensity of antigen expression and proportion of positive cases. CD10, CD11a, CD14, CD15, CD16, CD19, CD20, CD21, CD23, CD30, CD34, CD38, CD65, CD66, CD138, and HLA-DR were negative in BMMC from all SMCD and controls studied.
Abbreviations: NS, statistically not significant; ND, not determined.
Proportion of positive cases.
PE/Cy5 conjugated MoAbs.
PE-conjugated MoAbs.