Erythroid Parameters
| Strain . | Treatment . | RBC (×1012/L) . | Hb (mmol/L) . | MCV (fL) . | |||
|---|---|---|---|---|---|---|---|
| Day 0* . | Day 4† . | Day 0 . | Day 4 . | Day 0 . | Day 4 . | ||
| B6 (n = 6) | Untreated‡ | 9.1 ± 0.4 | 9.7 ± 0.5 | 45 ± 1 | |||
| Phenylhydrazine | 5.1 ± 0.61-153 | 7.9 ± 0.51-153 | 8.3 ± 1.4 | 8.5 ± 0.81-153 | 44 ± 1 | 56 ± 11-153 | |
| Phlebotomy | 8.5 ± 0.21-153 | 8.9 ± 0.2 | 8.7 ± 0.21-153 | 9.4 ± 0.2 | 46 ± 1 | 46 ± 0.11-153 | |
| Low dietary iron | 9.0 ± 0.8 | 9.2 ± 0.4 | 8.6 ± 0.51-153 | 9.7 ± 0.4 | 44 ± 1 | 45 ± 1 | |
| β2m−/− (n = 6) | Untreated‡ | 9.6 ± 0.21-155 | 10.8 ± 0.41-155 | 47 ± 11-155 | |||
| Phenylhydrazine | 7.4 ± 0.41-153,1-155 | 8.1 ± 0.31-153 | 11.4 ± 0.81-155 | 9.7 ± 0.31-153,1-155 | 46 ± 11-155 | 62 ± 11-153,1-155 | |
| Phlebotomy | 9.5 ± 0.31-155 | 9.6 ± 0.21-155 | 10.2 ± 0.41-153,1-155 | 10.8 ± 0.31-155 | 47 ± 11-155 | 48 ± 11-153,1-155 | |
| Low dietary iron | 9.0 ± 0.31-153 | 9.5 ± 0.1 | 9.4 ± 0.31-153,1-155 | 10.4 ± 0.41-155 | 46 ± 0.11-155 | 47 ± 11-155 | |
| Strain . | Treatment . | RBC (×1012/L) . | Hb (mmol/L) . | MCV (fL) . | |||
|---|---|---|---|---|---|---|---|
| Day 0* . | Day 4† . | Day 0 . | Day 4 . | Day 0 . | Day 4 . | ||
| B6 (n = 6) | Untreated‡ | 9.1 ± 0.4 | 9.7 ± 0.5 | 45 ± 1 | |||
| Phenylhydrazine | 5.1 ± 0.61-153 | 7.9 ± 0.51-153 | 8.3 ± 1.4 | 8.5 ± 0.81-153 | 44 ± 1 | 56 ± 11-153 | |
| Phlebotomy | 8.5 ± 0.21-153 | 8.9 ± 0.2 | 8.7 ± 0.21-153 | 9.4 ± 0.2 | 46 ± 1 | 46 ± 0.11-153 | |
| Low dietary iron | 9.0 ± 0.8 | 9.2 ± 0.4 | 8.6 ± 0.51-153 | 9.7 ± 0.4 | 44 ± 1 | 45 ± 1 | |
| β2m−/− (n = 6) | Untreated‡ | 9.6 ± 0.21-155 | 10.8 ± 0.41-155 | 47 ± 11-155 | |||
| Phenylhydrazine | 7.4 ± 0.41-153,1-155 | 8.1 ± 0.31-153 | 11.4 ± 0.81-155 | 9.7 ± 0.31-153,1-155 | 46 ± 11-155 | 62 ± 11-153,1-155 | |
| Phlebotomy | 9.5 ± 0.31-155 | 9.6 ± 0.21-155 | 10.2 ± 0.41-153,1-155 | 10.8 ± 0.31-155 | 47 ± 11-155 | 48 ± 11-153,1-155 | |
| Low dietary iron | 9.0 ± 0.31-153 | 9.5 ± 0.1 | 9.4 ± 0.31-153,1-155 | 10.4 ± 0.41-155 | 46 ± 0.11-155 | 47 ± 11-155 | |
Abbreviation: n, number of animals per group.
Day 0 refers to the day the test dose was applied.
Day 4 refers to the day iron retention was measured.
Plotted data from day 0 and day 4.
P < .05, comparison between untreated and treated mice.
P < .05, comparison between strains with the same treatment.