MOPPEBVCAD Hybrid Regimen: Drug Doses and Time Schedule, With Dose Reduction According to Blood Cell Counts
| Drugs . | Dose (mg/m2) . | Route . | Days . |
|---|---|---|---|
| Mechlorethamine (NH2) | 6 | IV | 1 cycles 1, 3, and 5, only |
| Lomustine (CCNU) | 100 | Oral | 1 cycles 2, 4, and 6, only |
| Vindesine (VDZ) | 3 | IV | 1 |
| Melphalan (Alk) | 6 | Oral | 1-3 |
| Prednisone (Pred) | 40 | Oral | 1-14 |
| Epidoxorubicin (Epi) | 40 | IV | 8 |
| Vincristine (VCR) | 1.4 | IV | 8 |
| Procarbazine (PCZ) | 100 | Oral | 8-14 |
| Vinblastine (VBL) | 6 | IV | 15 |
| Bleomycin (BLM) | 10 | IV | 15 |
| Drugs . | Dose (mg/m2) . | Route . | Days . |
|---|---|---|---|
| Mechlorethamine (NH2) | 6 | IV | 1 cycles 1, 3, and 5, only |
| Lomustine (CCNU) | 100 | Oral | 1 cycles 2, 4, and 6, only |
| Vindesine (VDZ) | 3 | IV | 1 |
| Melphalan (Alk) | 6 | Oral | 1-3 |
| Prednisone (Pred) | 40 | Oral | 1-14 |
| Epidoxorubicin (Epi) | 40 | IV | 8 |
| Vincristine (VCR) | 1.4 | IV | 8 |
| Procarbazine (PCZ) | 100 | Oral | 8-14 |
| Vinblastine (VBL) | 6 | IV | 15 |
| Bleomycin (BLM) | 10 | IV | 15 |
| Leukocyte Count (109/L) . | Platelet Count (109/L) . | Doses and Drugs . |
|---|---|---|
| >4 | >150 | 100% All drugs |
| 3.000-3.999 | 100-149 | 100% VCR, BLM, Pred, |
| 50% VBL, VDZ, Alk, HN2, Epi, CCNU, PCZ | ||
| 2.000-2.999 | 50-99 | 100% VCR, BLM, Pred |
| 25% VDZ, VBL, Alk, NH2, Epi, PCZ | ||
| 0% CCNU | ||
| 1.500-1.999 | 50-99 | 100% BLM, Pred |
| 50% VCR | ||
| 25% VDZ, VBL, Alk, NH2, Epi, PCZ | ||
| 0% CCNU | ||
| <1.500 | <50 | No drugs: reevaluation after 1 wk |
| Leukocyte Count (109/L) . | Platelet Count (109/L) . | Doses and Drugs . |
|---|---|---|
| >4 | >150 | 100% All drugs |
| 3.000-3.999 | 100-149 | 100% VCR, BLM, Pred, |
| 50% VBL, VDZ, Alk, HN2, Epi, CCNU, PCZ | ||
| 2.000-2.999 | 50-99 | 100% VCR, BLM, Pred |
| 25% VDZ, VBL, Alk, NH2, Epi, PCZ | ||
| 0% CCNU | ||
| 1.500-1.999 | 50-99 | 100% BLM, Pred |
| 50% VCR | ||
| 25% VDZ, VBL, Alk, NH2, Epi, PCZ | ||
| 0% CCNU | ||
| <1.500 | <50 | No drugs: reevaluation after 1 wk |
When leukocytes are less than 3.0 and/or platelets are less than 100 × 109/L before the start of a new cycle, a 1 week delay is preferred to dose reductions.
Abbreviation: IV, intravenous.