Patients With Confirmed or Suspect BLPD
| Case No. . | Sex/ Age . | Disease . | Donor . | Transplant Date . | Rejection Prophylaxis . | T-Cell Depletion Method . | GVHD Prophylaxis . | Graft Failure . | Acute GVHD . | Chronic GVHD . | Day of Diagnosis . | Survival (d) . | Comments . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F/30 | AML | HLA-id sib | Nov 02, 84 | None | CP-1M in vitro | None | No | No | No | 270 | D 270 | |
| 2 | M/36 | CML | HLA-id sib | Jun 11, 86 | None | CP-1M in vitro | None | No | No | No | 522 | D 522 | Possibly relapse, not BLPD |
| 3 | M/29 | CML | HLA-id sib | Mar 5, 87 | None | CP-1G in vitro | CyA | No | Yes | No | 118 | D 139 | |
| 4 | M/48 | CML | Unrelated | July 20, 87 | CP-1G | CP-1M in vitro | None | No | Yes | Yes | 122 | D 122 | |
| 5 | M/1 | Thal | Non-id family | July 13, 88 | None | CP-1M in vitro | None | No | No | No | 120 | D 122 | |
| 6 | F/39 | CML | Unrelated | Apr 19, 90 | CP-1G | CP-1G in vitro | CyA | No | Yes | NA | 85 | D 87 | |
| 7 | F/17 | AML | HLA-id sib | Jul 16, 90 | CP-1G | CP-1M in vitro | None | No | No | No | 205 | A 300 | Lost to follow-up |
| 8 | M/3 | WA | Parent | Dec 22, 90 | CP-1G, LFA-1 | E-rosette | CyA | No | No | NA | 32 | D 40 | |
| 9 | M/41 | CML | Unrelated | Feb 22, 91 | CP-1G | CP-1M in vitro | CyA | No | Yes | NA | 108 | D 108 | |
| 10 | F/6 | AML | Unrelated | Mar 7, 91 | CP-1G, LFA-1 | E-rosette | CyA | No | No | NA | 81 | D 87 | |
| 11 | F/7 | AML | Unrelated | Feb 13, 92 | CP-1G, LFA-1 | E-rosette | Mtx/CyA | No | Yes | Yes | 55 | D 124 | |
| 12 | M/8 | CML | Unrelated | Aug 13, 92 | CP-1G, LFA-1 | E-rosette | Mtx/CyA | No | Yes | No | 80 | D 125 | |
| 13 | F/15 | ALL | Unrelated | Sep 17, 92 | CP-1G, LFA-1 | E-rosette | Mtx/CyA | No | No | NA | 59 | D 82 | |
| 14 | M/26 | CML | Unrelated | Oct 14, 92 | CP-1G | CP-1G in vivo | Mtx/CyA | No | Yes | NA | 116 | D 116 | |
| 15 | F/43 | CML | HLA-id sib | Oct 29, 92 | CP-1G | CP-1G in vitro | None | No | No | No | 177 | D 245 | |
| 16 | M/13 | ALD | Unrelated | Jul 5, 93 | CP-1G, LFA-1 | CP-1M in vitro | Mtx/CyA | Yes | NA | NA | 59 | D 71 | |
| 17 | M/61 | MDS | HLA-id sib | May 9, 94 | CP-1G | CP-1M in vitro | None | Yes | NA | NA | 231 | D 236 | |
| 18 | F/40 | CML | HLA-id sib | Jul 5, 95 | None | CP-1G in vitro | None | No | Yes | 347 | D 370 | ||
| 19 | F/31 | CML | Unrelated | Sep 15, 95 | CP-1G | CP-1G in vivo | Mtx/CyA | No | Yes | Yes | 162 | D 180 | |
| 20 | M/48 | CML | HLA-id sib | Oct 6, 95 | None | CP-1M in vitro | CyA | No | No | No | 244 | A 540 | Responded to donor T cells |
| Case No. . | Sex/ Age . | Disease . | Donor . | Transplant Date . | Rejection Prophylaxis . | T-Cell Depletion Method . | GVHD Prophylaxis . | Graft Failure . | Acute GVHD . | Chronic GVHD . | Day of Diagnosis . | Survival (d) . | Comments . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F/30 | AML | HLA-id sib | Nov 02, 84 | None | CP-1M in vitro | None | No | No | No | 270 | D 270 | |
| 2 | M/36 | CML | HLA-id sib | Jun 11, 86 | None | CP-1M in vitro | None | No | No | No | 522 | D 522 | Possibly relapse, not BLPD |
| 3 | M/29 | CML | HLA-id sib | Mar 5, 87 | None | CP-1G in vitro | CyA | No | Yes | No | 118 | D 139 | |
| 4 | M/48 | CML | Unrelated | July 20, 87 | CP-1G | CP-1M in vitro | None | No | Yes | Yes | 122 | D 122 | |
| 5 | M/1 | Thal | Non-id family | July 13, 88 | None | CP-1M in vitro | None | No | No | No | 120 | D 122 | |
| 6 | F/39 | CML | Unrelated | Apr 19, 90 | CP-1G | CP-1G in vitro | CyA | No | Yes | NA | 85 | D 87 | |
| 7 | F/17 | AML | HLA-id sib | Jul 16, 90 | CP-1G | CP-1M in vitro | None | No | No | No | 205 | A 300 | Lost to follow-up |
| 8 | M/3 | WA | Parent | Dec 22, 90 | CP-1G, LFA-1 | E-rosette | CyA | No | No | NA | 32 | D 40 | |
| 9 | M/41 | CML | Unrelated | Feb 22, 91 | CP-1G | CP-1M in vitro | CyA | No | Yes | NA | 108 | D 108 | |
| 10 | F/6 | AML | Unrelated | Mar 7, 91 | CP-1G, LFA-1 | E-rosette | CyA | No | No | NA | 81 | D 87 | |
| 11 | F/7 | AML | Unrelated | Feb 13, 92 | CP-1G, LFA-1 | E-rosette | Mtx/CyA | No | Yes | Yes | 55 | D 124 | |
| 12 | M/8 | CML | Unrelated | Aug 13, 92 | CP-1G, LFA-1 | E-rosette | Mtx/CyA | No | Yes | No | 80 | D 125 | |
| 13 | F/15 | ALL | Unrelated | Sep 17, 92 | CP-1G, LFA-1 | E-rosette | Mtx/CyA | No | No | NA | 59 | D 82 | |
| 14 | M/26 | CML | Unrelated | Oct 14, 92 | CP-1G | CP-1G in vivo | Mtx/CyA | No | Yes | NA | 116 | D 116 | |
| 15 | F/43 | CML | HLA-id sib | Oct 29, 92 | CP-1G | CP-1G in vitro | None | No | No | No | 177 | D 245 | |
| 16 | M/13 | ALD | Unrelated | Jul 5, 93 | CP-1G, LFA-1 | CP-1M in vitro | Mtx/CyA | Yes | NA | NA | 59 | D 71 | |
| 17 | M/61 | MDS | HLA-id sib | May 9, 94 | CP-1G | CP-1M in vitro | None | Yes | NA | NA | 231 | D 236 | |
| 18 | F/40 | CML | HLA-id sib | Jul 5, 95 | None | CP-1G in vitro | None | No | Yes | 347 | D 370 | ||
| 19 | F/31 | CML | Unrelated | Sep 15, 95 | CP-1G | CP-1G in vivo | Mtx/CyA | No | Yes | Yes | 162 | D 180 | |
| 20 | M/48 | CML | HLA-id sib | Oct 6, 95 | None | CP-1M in vitro | CyA | No | No | No | 244 | A 540 | Responded to donor T cells |
Abbreviations: AML, acute myeloid leukemia; CML, chronic myeloid leukemia; Thal, thalassemia; WA, Wiskott-Aldrich syndrome; ALL, acute lymphocytic leukemia; ALD, adrenoleukodystropy; MDS, myelodysplastic syndrome; NA, not applicable.