Effect of DT388-GMCSF on Normal Bone Marrow CFC
| Progenitor . | n . | % Surviving* (X ± SEM) . |
|---|---|---|
| CFU-E | 4 | 48 ± 31 |
| BFU-E | 4 | 64 ± 24 |
| CFU-GM | 4 | 66 ± 27 |
| CFU-GEMM | 4 | 40 ± 8 |
| CFU-Mk | 3 | 69 ± 87 |
| Total CFC | 4 | 56 ± 33 |
| Progenitor . | n . | % Surviving* (X ± SEM) . |
|---|---|---|
| CFU-E | 4 | 48 ± 31 |
| BFU-E | 4 | 64 ± 24 |
| CFU-GM | 4 | 66 ± 27 |
| CFU-GEMM | 4 | 40 ± 8 |
| CFU-Mk | 3 | 69 ± 87 |
| Total CFC | 4 | 56 ± 33 |
*After 48 hours of incubation with DT388-GMCSF at 4 × 10−9 mol/L by comparison to controls incubated under the same conditions but in the absence of DT388-GMCSF. The values for total CFC, CFU-E, BFU-E, CFU-GM, and CFU-Mk do not differ significantly from 100% (P > .05). The values for CFU-GEMM are significantly reduced from control values (P < .001).