Correlation Between LC50 Values in 166 Childhood ALL Samples Expressed by Spearman's Rank Correlation Coefficients
. | DXM . | ASP . | VCR . | VDS . | DNR . | DOX . | MIT . | 6MP . | 6TG . | ARA . | TEN . | IFM . |
---|---|---|---|---|---|---|---|---|---|---|---|---|
PRD | 0.84 | 0.42 | 0.38 | 0.30 | 0.45 | 0.47 | 0.46 | 0.43 | 0.41 | 0.36 | 0.46 | 0.30 |
DXM | — | 0.41 | 0.34 | 0.38 | 0.57 | 0.44 | 0.44 | 0.41 | 0.36 | 0.29 | 0.40 | 0.28 |
ASP | — | 0.34 | 0.30 | 0.33 | 0.37 | 0.31 | 0.49 | 0.49 | 0.31 | 0.24 | 0.53 | |
VCR | — | 0.72 | 0.45 | 0.53 | 0.59 | 0.32 | 0.38 | 0.49 | 0.49 | 0.41 | ||
VDS | — | 0.42 | 0.62 | 0.62 | 0.29 | 0.35 | 0.40 | 0.62 | 0.42 | |||
DNR | — | 0.62 | 0.59 | 0.22 | 0.36 | 0.35 | 0.57 | 0.41 | ||||
DOX | — | 0.79 | 0.36 | 0.49 | 0.39 | 0.74 | 0.48 | |||||
MIT | — | 0.31 | 0.38 | 0.38 | 0.72 | 0.47 | ||||||
6MP | — | 0.60 | 0.49 | 0.40 | 0.31 | |||||||
6TG | — | 0.42 | 0.46 | 0.43 | ||||||||
ARA | — | 0.45 | 0.46 | |||||||||
TEN | — | 0.49 |
. | DXM . | ASP . | VCR . | VDS . | DNR . | DOX . | MIT . | 6MP . | 6TG . | ARA . | TEN . | IFM . |
---|---|---|---|---|---|---|---|---|---|---|---|---|
PRD | 0.84 | 0.42 | 0.38 | 0.30 | 0.45 | 0.47 | 0.46 | 0.43 | 0.41 | 0.36 | 0.46 | 0.30 |
DXM | — | 0.41 | 0.34 | 0.38 | 0.57 | 0.44 | 0.44 | 0.41 | 0.36 | 0.29 | 0.40 | 0.28 |
ASP | — | 0.34 | 0.30 | 0.33 | 0.37 | 0.31 | 0.49 | 0.49 | 0.31 | 0.24 | 0.53 | |
VCR | — | 0.72 | 0.45 | 0.53 | 0.59 | 0.32 | 0.38 | 0.49 | 0.49 | 0.41 | ||
VDS | — | 0.42 | 0.62 | 0.62 | 0.29 | 0.35 | 0.40 | 0.62 | 0.42 | |||
DNR | — | 0.62 | 0.59 | 0.22 | 0.36 | 0.35 | 0.57 | 0.41 | ||||
DOX | — | 0.79 | 0.36 | 0.49 | 0.39 | 0.74 | 0.48 | |||||
MIT | — | 0.31 | 0.38 | 0.38 | 0.72 | 0.47 | ||||||
6MP | — | 0.60 | 0.49 | 0.40 | 0.31 | |||||||
6TG | — | 0.42 | 0.46 | 0.43 | ||||||||
ARA | — | 0.45 | 0.46 | |||||||||
TEN | — | 0.49 |
All correlations were statistically significant, and printed bold if >.50.
Abbreviations: PRD, prednisolone; DXM, dexamethasone; ASP, l-asparaginase; VCR, vincristine; VDS, vindesine; DNR, daunorubicin; DOX, doxorubicin; MIT, mitoxantrone; 6MP, mercaptopurine; 6TG, thioguanine; ARA, cytarabine; TEN, teniposide; IFM, 4-hydroperoxy-ifosfamide.