Proportion of Leukemic Cells in the Engrafted Marrow
| Patient* . | Disease Stage . | Engraftment (%)† . | % of Ph-Positive Cells in the Graft‡ . | |
|---|---|---|---|---|
| huCD45 . | FISH . | |||
| CP2 | CP | 4 | 7 | 85 |
| 4.1 | 4.8 | 94 | ||
| CP3 | CP | 4 | 5.8 | 100 |
| CP5/a | CP | 3.8 | 3 | 100 |
| CP5/b | 6.5 | 6 | 100 | |
| CP5/c | 4.8 | 4 | 100 | |
| CP5/d | 4 | 5 | 100 | |
| CP6 | CP | 10 | 9.1 | 70.6 |
| CP8 | CP | 2.3 | 3 | 100 |
| 4.1 | 5 | 100 | ||
| 5 | 5 | 100 | ||
| CP10 | CP | 7 | 7.7 | 77 |
| AP1 | AP | 18 | 22 | 100 |
| AP3/a | AP | 36 | 31 | 100 |
| AP3/b | 20 | 19 | 100 | |
| BP4/a | BP | 34 | 30 | 100 |
| BP4/b | 49 | 45 | 100 | |
| Patient* . | Disease Stage . | Engraftment (%)† . | % of Ph-Positive Cells in the Graft‡ . | |
|---|---|---|---|---|
| huCD45 . | FISH . | |||
| CP2 | CP | 4 | 7 | 85 |
| 4.1 | 4.8 | 94 | ||
| CP3 | CP | 4 | 5.8 | 100 |
| CP5/a | CP | 3.8 | 3 | 100 |
| CP5/b | 6.5 | 6 | 100 | |
| CP5/c | 4.8 | 4 | 100 | |
| CP5/d | 4 | 5 | 100 | |
| CP6 | CP | 10 | 9.1 | 70.6 |
| CP8 | CP | 2.3 | 3 | 100 |
| 4.1 | 5 | 100 | ||
| 5 | 5 | 100 | ||
| CP10 | CP | 7 | 7.7 | 77 |
| AP1 | AP | 18 | 22 | 100 |
| AP3/a | AP | 36 | 31 | 100 |
| AP3/b | 20 | 19 | 100 | |
| BP4/a | BP | 34 | 30 | 100 |
| BP4/b | 49 | 45 | 100 | |
*Patient identification numbers refer to those reported in Table1. Letters a to d refer to the number of mice injected with the same sample.
Percentage of human cells in mouse BM detected by staining with human CD45 MoAbs. FISH results refer to the percentage of BCR and ABL (normal) and BCR-ABL (leukemic) positive cells in the mouse BM.
Percentage of leukemic (BCR-ABL-positive) cells in the graft (human cells) obtained after injection of cells from the different patients as detected by FISH analysis.