Expression of HLA Class I, TAP 1, and TAP 2 in H-RS Cells
| HD Case . | Subtype . | EBV Status . | HLA Class I . | TAP 1 . | TAP 2 . | |
|---|---|---|---|---|---|---|
| EBER in situ Hybridization . | LMP 1 Staining . | |||||
| 1 | MC | + | + | +++ | ++ | ++ |
| 2 | MC | + | + | +++ | ++ | ++ |
| 3 | MC | + | + | + | + | + |
| 4 | MC | + | + | +++ | +++ | +++ |
| 5 | MC | + | + | ++ | + | ++ |
| 6 | MC | + | + | ++ | ++ | ++ |
| 7 | NS | + | + | ++ | ++ | ++ |
| 8 | NS | + | + | ++ | ++ | ++ |
| 9 | NS | + | + | ++ | ++ | + |
| 10 | NS | + | + | ++ | ++ | + |
| 11 | NS | + | + | ++ | ++ | ++ |
| 12 | NS | + | + | ++ | ++ | ++ |
| 13 | NS | + | + | + | + | ++ |
| 14 | NS | + | + | ++ | ++ | + |
| 15 | NS | + | + | ++ | + | ++ |
| 16 | NS | + | + | + | +++ | ++ |
| 17 | NS | + | + | − | + | +/− |
| 18 | NS | + | + | − | ++ | +/− |
| 19 | NS | + | + | − | ++ | ++ |
| 20 | NS | + | + | − | ++ | ++ |
| 21 | LP | + | + | +/− | +++ | + |
| 22 | LP | + | + | − | ++ | ++ |
| 23 | IF | + | + | ++ | ++ | ++ |
| 24 | IF | + | + | ++ | ++ | ++ |
| 25 | MC | − | − | ++ | ++ | ++ |
| 26 | MC | − | − | +/− | +++ | +++ |
| 27 | NS | − | − | ++ | ++ | +++ |
| 28 | NS | − | − | − | +++ | ++ |
| 29 | NS | − | − | − | +++ | ++ |
| 30 | NS | − | − | − | ++ | ++ |
| 31 | NS | − | − | − | ++ | ++ |
| 32 | NS | − | − | − | ++ | ++ |
| 33 | NS | − | − | − | ++ | ++ |
| 34 | LP | − | − | +/− | ++ | ++ |
| 35 | LP | − | − | − | +++ | +++ |
| 36 | LP | − | − | − | +/− | ++ |
| 37 | ni | − | − | + | + | + |
| 38 | ni | − | − | + | ++ | ++ |
| HD Case . | Subtype . | EBV Status . | HLA Class I . | TAP 1 . | TAP 2 . | |
|---|---|---|---|---|---|---|
| EBER in situ Hybridization . | LMP 1 Staining . | |||||
| 1 | MC | + | + | +++ | ++ | ++ |
| 2 | MC | + | + | +++ | ++ | ++ |
| 3 | MC | + | + | + | + | + |
| 4 | MC | + | + | +++ | +++ | +++ |
| 5 | MC | + | + | ++ | + | ++ |
| 6 | MC | + | + | ++ | ++ | ++ |
| 7 | NS | + | + | ++ | ++ | ++ |
| 8 | NS | + | + | ++ | ++ | ++ |
| 9 | NS | + | + | ++ | ++ | + |
| 10 | NS | + | + | ++ | ++ | + |
| 11 | NS | + | + | ++ | ++ | ++ |
| 12 | NS | + | + | ++ | ++ | ++ |
| 13 | NS | + | + | + | + | ++ |
| 14 | NS | + | + | ++ | ++ | + |
| 15 | NS | + | + | ++ | + | ++ |
| 16 | NS | + | + | + | +++ | ++ |
| 17 | NS | + | + | − | + | +/− |
| 18 | NS | + | + | − | ++ | +/− |
| 19 | NS | + | + | − | ++ | ++ |
| 20 | NS | + | + | − | ++ | ++ |
| 21 | LP | + | + | +/− | +++ | + |
| 22 | LP | + | + | − | ++ | ++ |
| 23 | IF | + | + | ++ | ++ | ++ |
| 24 | IF | + | + | ++ | ++ | ++ |
| 25 | MC | − | − | ++ | ++ | ++ |
| 26 | MC | − | − | +/− | +++ | +++ |
| 27 | NS | − | − | ++ | ++ | +++ |
| 28 | NS | − | − | − | +++ | ++ |
| 29 | NS | − | − | − | +++ | ++ |
| 30 | NS | − | − | − | ++ | ++ |
| 31 | NS | − | − | − | ++ | ++ |
| 32 | NS | − | − | − | ++ | ++ |
| 33 | NS | − | − | − | ++ | ++ |
| 34 | LP | − | − | +/− | ++ | ++ |
| 35 | LP | − | − | − | +++ | +++ |
| 36 | LP | − | − | − | +/− | ++ |
| 37 | ni | − | − | + | + | + |
| 38 | ni | − | − | + | ++ | ++ |
Abbreviations: MC, mixed cellularity; NS, nodular sclerosing; LP, lymphocyte predominant; IF, interfollicular HD; ni, not interpretable; −, no staining; +/−, only some cells positive; +, weak staining; ++, medium staining; +++, strong staining.