Metaphase Cytogenetic Results in Seven Patients With a p53 Gene Deletion by Interphase FISH
| Patient . | Karyotype . | Interphase FISH . | ||
|---|---|---|---|---|
| No. 17-Centromere . | p53 . | D17S34 . | ||
| 1/GN | Hypodiploid (38-45),XX,der(1),del(1)(p12),−4,inv(6)(p12p25)/−6,del(10)(q21),−10, t(11;?) (q10;?),dic(16;?)(p13;?),add(17)(p13),der(17), add(22)(p13)/trc(22;?;?)(p13;?;?),+3mar[cp15]/46,XX[5] | 2 Signals | 1 Signal | 2-3 Signals |
| 2/NN | 52,XY,+t(1;16)(p10;p10,+3,+5,+ins(7;?)(p21;?),+9,+del(11)(q13),−13,−14, +15,−16,+17,+18,+19,+21[cp5]/106,idemx2[1]/46,XY[12] | 3 Signals | 1 Signal | 3 Signals |
| 3/FJ | 50,XX,del(1)(p34),+dic(1;18)(p12;q21),+t(1;16)(p10;p11),+add(3)(p22), der(4),+5,del(6)(q13q25),−13,−16,+19,−20,+21,−22[5]/46,XX[11] | 2 Signals | 1 Signal | 2 Signals |
| 4/EB | 53,XX,+3,+5,+7,+9,del(11)(q23),del(13)(q13q32),+15,+19,+mar[1]/46,XY[61] | 2 Signals | 1 Signal | 2 Signals |
| 5/RB | 40,XY,+t(1;16)(p10;p10)x2,−5,−10,−10,−13,−14,−16,−16,−21[1]/45,X, −Y[13]/46,XY[49] | 2 Signals | 1 Signal | 2 Signals |
| 6/RE | Hypodiploid(36-45),X,− X,dic(1;15)(q10;q26),t(2;10)(q14;p13),add(3)(q29), add(7)(p22),−8,var del(11)(q11/q14),der(12),−13,add(16)(q24),+2dicmar[cp20] | 2 Signals | 1 Signal | 2 Signals |
| 7/MS | 46,XX[19] | 2 Signals | 1 Signal | 2 Signals |
| Patient . | Karyotype . | Interphase FISH . | ||
|---|---|---|---|---|
| No. 17-Centromere . | p53 . | D17S34 . | ||
| 1/GN | Hypodiploid (38-45),XX,der(1),del(1)(p12),−4,inv(6)(p12p25)/−6,del(10)(q21),−10, t(11;?) (q10;?),dic(16;?)(p13;?),add(17)(p13),der(17), add(22)(p13)/trc(22;?;?)(p13;?;?),+3mar[cp15]/46,XX[5] | 2 Signals | 1 Signal | 2-3 Signals |
| 2/NN | 52,XY,+t(1;16)(p10;p10,+3,+5,+ins(7;?)(p21;?),+9,+del(11)(q13),−13,−14, +15,−16,+17,+18,+19,+21[cp5]/106,idemx2[1]/46,XY[12] | 3 Signals | 1 Signal | 3 Signals |
| 3/FJ | 50,XX,del(1)(p34),+dic(1;18)(p12;q21),+t(1;16)(p10;p11),+add(3)(p22), der(4),+5,del(6)(q13q25),−13,−16,+19,−20,+21,−22[5]/46,XX[11] | 2 Signals | 1 Signal | 2 Signals |
| 4/EB | 53,XX,+3,+5,+7,+9,del(11)(q23),del(13)(q13q32),+15,+19,+mar[1]/46,XY[61] | 2 Signals | 1 Signal | 2 Signals |
| 5/RB | 40,XY,+t(1;16)(p10;p10)x2,−5,−10,−10,−13,−14,−16,−16,−21[1]/45,X, −Y[13]/46,XY[49] | 2 Signals | 1 Signal | 2 Signals |
| 6/RE | Hypodiploid(36-45),X,− X,dic(1;15)(q10;q26),t(2;10)(q14;p13),add(3)(q29), add(7)(p22),−8,var del(11)(q11/q14),der(12),−13,add(16)(q24),+2dicmar[cp20] | 2 Signals | 1 Signal | 2 Signals |
| 7/MS | 46,XX[19] | 2 Signals | 1 Signal | 2 Signals |