Published Series on Secondary Malignancies in HCL Patients
| Author . | Year . | No. . | Age . | M:F . | FU . | Treatment . | 2nd Ca . | % . | Skin . | Pros . | Lung . | GI . | Hem . | NHL . | HD . | RCC . | Br . | Sar . | Others . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jacobs7 | 1975-1984 | 172 | NA | NA | 60 | S/Chl/IFN | 14 | 7.5 | 5 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | |||
| Bernstein24 | 1972-1987 | 208 | NA | 4.0:1 | NA | NA | 30 | 14.4 | 3 | 6 | 4 | 1 | 16 | ||||||
| Berman23 | 1984-1990 | 35 | 52 | 6.0:1 | 44 | IFN | 1 | 2 | 1 | ||||||||||
| Smith26 | 1984-1990 | 56 | 52 | 4.6:1 | 72 | S/IFN | 3 | 5 | 2 | 1 | |||||||||
| Kraut4 | 1987-1994 | 24 | NA | NA | 82 | DCF | 4 | 16 | 3 | 1 | |||||||||
| Kamperier12 | 1983-1986 | 69 | 53 | 7.6:1 | 91 | Chl/DCF/IFN | 13 | 19 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | ||||
| Troussard28 | 1966-1993 | 107 | 51 | 8.7:1 | 102 | IFN | 11 | 10.2 | 3 | 1 | 1 | 2 | 2 | 2 | |||||
| Frassoldati25 | 1965-1990 | 725 | 54 | 3.9:1 | NA | S/IFN/DCF/2CDA | 22 | 3.7 | 3 | 3 | 3 | 5 | 1 | 3 | 2 | 2 | |||
| Pawson29 | 1988-1995 | 200 | 48 | 4.9:1 | 65 | IFN/DCF/2CDA | 8 | 4 | 2 | 2 | 1 | 1 | 2 | ||||||
| Lauria27 | 1991-1994 | 40 | 54 | 3.0:1 | 48 | IFN/2CDA | 2 | 5 | 1 | 1 | |||||||||
| Kurzrock13 | 1968-1995 | 350 | 50 | 4.3:1 | 72 | IFN/DCF/2CDA | 26 | 7.4 | 6 | 4 | 2 | 4 | 2 | 3 | 1 | 1 | 2 | 3 | |
| Au | 1976-1996 | 117 | 53 | 3.3:1 | 68 | S/IFN/DCF/2CDA | 25 | 22 | 9 | 8 | 2 | 4 | 1 | 1 | 1 | 1 | 1 | 5 | |
| Total | 2,103 | 159 | 31 | 23 | 16 | 23 | 10 | 12 | 3 | 4 | 8 | 4 | 35 |
| Author . | Year . | No. . | Age . | M:F . | FU . | Treatment . | 2nd Ca . | % . | Skin . | Pros . | Lung . | GI . | Hem . | NHL . | HD . | RCC . | Br . | Sar . | Others . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jacobs7 | 1975-1984 | 172 | NA | NA | 60 | S/Chl/IFN | 14 | 7.5 | 5 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | |||
| Bernstein24 | 1972-1987 | 208 | NA | 4.0:1 | NA | NA | 30 | 14.4 | 3 | 6 | 4 | 1 | 16 | ||||||
| Berman23 | 1984-1990 | 35 | 52 | 6.0:1 | 44 | IFN | 1 | 2 | 1 | ||||||||||
| Smith26 | 1984-1990 | 56 | 52 | 4.6:1 | 72 | S/IFN | 3 | 5 | 2 | 1 | |||||||||
| Kraut4 | 1987-1994 | 24 | NA | NA | 82 | DCF | 4 | 16 | 3 | 1 | |||||||||
| Kamperier12 | 1983-1986 | 69 | 53 | 7.6:1 | 91 | Chl/DCF/IFN | 13 | 19 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | ||||
| Troussard28 | 1966-1993 | 107 | 51 | 8.7:1 | 102 | IFN | 11 | 10.2 | 3 | 1 | 1 | 2 | 2 | 2 | |||||
| Frassoldati25 | 1965-1990 | 725 | 54 | 3.9:1 | NA | S/IFN/DCF/2CDA | 22 | 3.7 | 3 | 3 | 3 | 5 | 1 | 3 | 2 | 2 | |||
| Pawson29 | 1988-1995 | 200 | 48 | 4.9:1 | 65 | IFN/DCF/2CDA | 8 | 4 | 2 | 2 | 1 | 1 | 2 | ||||||
| Lauria27 | 1991-1994 | 40 | 54 | 3.0:1 | 48 | IFN/2CDA | 2 | 5 | 1 | 1 | |||||||||
| Kurzrock13 | 1968-1995 | 350 | 50 | 4.3:1 | 72 | IFN/DCF/2CDA | 26 | 7.4 | 6 | 4 | 2 | 4 | 2 | 3 | 1 | 1 | 2 | 3 | |
| Au | 1976-1996 | 117 | 53 | 3.3:1 | 68 | S/IFN/DCF/2CDA | 25 | 22 | 9 | 8 | 2 | 4 | 1 | 1 | 1 | 1 | 1 | 5 | |
| Total | 2,103 | 159 | 31 | 23 | 16 | 23 | 10 | 12 | 3 | 4 | 8 | 4 | 35 |
Abbreviations: No., number of patients in study; M:F, male to female ratio; FU, median follow up time in months; 2nd Ca, number of second malignancies. Pros, prostate cancer; GI, gastrointestinal cancer; Hem, hematological malignancy; NHL, non-Hodgkin’s lymphoma; HD, Hodgkin’s disease; RCC, renal cell carcinoma; Br, breast cancer; Sar, sarcoma; NA, not available; S, splenectomy; Chl, chlormabucil; IFN, interferon.