Table 1.

Enhancement of Histamine Release by Two Indolylmaleimides From Basophils Sensitized With Anti-gp120 IgE and Stimulated With gp120-OVA

Sensitized With (ng/mL)Stimulated With 50 ng/mL gp120-OVA
−BIS+BIS-150−Ro +Ro-151
5,000  64-152 71 ± 2  64 94 ± 13  
2,000  54  66 ± 3  48  74 ± 5 
800  44  52 ± 2  31  50 ± 1  
320  20 30 ± 3  11  24 ± 4 
Sensitized With (ng/mL)Stimulated With 50 ng/mL gp120-OVA
−BIS+BIS-150−Ro +Ro-151
5,000  64-152 71 ± 2  64 94 ± 13  
2,000  54  66 ± 3  48  74 ± 5 
800  44  52 ± 2  31  50 ± 1  
320  20 30 ± 3  11  24 ± 4 

Two different groups of donors were used for experiments with BIS II and Ro-31-8220.

F0-150

BIS = 400 nmol/L bisindolylmaleimide II, n = 3.

F0-151

Ro = 500 nmol/L Ro-31-8220, n = 3.

F0-152

% histamine release, errors represent SEM.

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