Allele Frequencies of 4 Dimorphic Markers of the Factor II Gene in Normals and Subjects Bearing G20210A
| Polymorphism . | Allele* . | Normals (N = 110) . | Heterozygotes (N = 123) . | Homozygotes (N = 10) . | χ2 Analysis (P) . |
|---|---|---|---|---|---|
| Intron D | T | 0.75 | 0.88 | 1.00† | .0007 |
| T3728C | C | 0.25 | 0.12 | 0.00 | |
| Intron E | C | 0.65 | 0.87 | 0.95 | <.0001 |
| C4125G | G | 0.35 | 0.13 | 0.05 | |
| Exon 10 | G | 0.84 | 0.96 | 1.00 | <.0001 |
| G8845A | A | 0.16 | 0.04 | 0.00 | |
| Intron M | A | 0.45 | 0.77 | 0.95 | <.0001 |
| G19911A | G | 0.55 | 0.23 | 0.05 |
| Polymorphism . | Allele* . | Normals (N = 110) . | Heterozygotes (N = 123) . | Homozygotes (N = 10) . | χ2 Analysis (P) . |
|---|---|---|---|---|---|
| Intron D | T | 0.75 | 0.88 | 1.00† | .0007 |
| T3728C | C | 0.25 | 0.12 | 0.00 | |
| Intron E | C | 0.65 | 0.87 | 0.95 | <.0001 |
| C4125G | G | 0.35 | 0.13 | 0.05 | |
| Exon 10 | G | 0.84 | 0.96 | 1.00 | <.0001 |
| G8845A | A | 0.16 | 0.04 | 0.00 | |
| Intron M | A | 0.45 | 0.77 | 0.95 | <.0001 |
| G19911A | G | 0.55 | 0.23 | 0.05 |
*The underlined nt are those present in the founder haplotype.
Based only on 8 homozygotes.