MLL Gene Rearrangements Detected by Southern Blot Analysis
| Patients . | Molecular Analysis of MLL Gene . | ||
|---|---|---|---|
| HindIII PS/98/4.2 . | EcoRI PS/98/4.2 . | BamHI PS/98/4.2 . | |
| ;A. t(4;11)+, std PCR−, nested PCR+ | |||
| INF-6 | R/R/R | R/G/G | R/R/R |
| PEDS-87 | G/R/G | R/G/G | G/G/G |
| ;B. t(4;11)−, std PCR−, nested PCR+ | |||
| PEDS-27 | R/G/R | G/G/G | R/G/G |
| PEDS-44 | R/G/R | G/G/G | R/G/R |
| PEDS-59 | NE | G/G/G | NE |
| PEDS-5 | NE/R/NE | R/G/NE | R/R/R |
| PEDS-106 | G/G/G | G/G/G | NE |
| ;C. t(4;11)+, std PCR+, nested PCR+ | |||
| INF-12 | R/R/R | G/G/G | R/G/R |
| PEDS-91 | G/R/G | G/R/G | G/G/NE |
| D. Normal cells | |||
| FL-12 (21 wk) | G/G/G | G/G/G | G/G/G |
| FL-14 (19 wk) | G/G/G | G/G/G | G/G/G |
| Normal BM4 | G/G/NE | G/G/NE | G/NE/NE |
| Patients . | Molecular Analysis of MLL Gene . | ||
|---|---|---|---|
| HindIII PS/98/4.2 . | EcoRI PS/98/4.2 . | BamHI PS/98/4.2 . | |
| ;A. t(4;11)+, std PCR−, nested PCR+ | |||
| INF-6 | R/R/R | R/G/G | R/R/R |
| PEDS-87 | G/R/G | R/G/G | G/G/G |
| ;B. t(4;11)−, std PCR−, nested PCR+ | |||
| PEDS-27 | R/G/R | G/G/G | R/G/G |
| PEDS-44 | R/G/R | G/G/G | R/G/R |
| PEDS-59 | NE | G/G/G | NE |
| PEDS-5 | NE/R/NE | R/G/NE | R/R/R |
| PEDS-106 | G/G/G | G/G/G | NE |
| ;C. t(4;11)+, std PCR+, nested PCR+ | |||
| INF-12 | R/R/R | G/G/G | R/G/R |
| PEDS-91 | G/R/G | G/R/G | G/G/NE |
| D. Normal cells | |||
| FL-12 (21 wk) | G/G/G | G/G/G | G/G/G |
| FL-14 (19 wk) | G/G/G | G/G/G | G/G/G |
| Normal BM4 | G/G/NE | G/G/NE | G/NE/NE |
Genomic DNA samples from leukemic or normal cells were examined for the presence of MLL gene rearrangements by Southern blot analysis, as described in Materials and Methods.
Abbreviations: R, rearranged; G, germline; NE, not examined; std, standard.