Table 3.

Neutrophil Phenotype in PU.1-Null Mice Compared With Normal Mice

 Normal  PU.1 Null  Normal  PU.1 Null  
Gr-1P +  +  FcγRII/IIIP +  + 
CAEP +  +  MPOP/R +  + 
CD18P +  +  CathepsinGR + +  
CD11bP +  −  ElastaseR +  +  
G-CSFRP +  − LysozymeR +  −  
GM-CSFRP + −  LactoferrinR +  ± 
IL-8RR +  +  GelatinaseR + −  
fMLPRR +  +     
 Normal  PU.1 Null  Normal  PU.1 Null  
Gr-1P +  +  FcγRII/IIIP +  + 
CAEP +  +  MPOP/R +  + 
CD18P +  +  CathepsinGR + +  
CD11bP +  −  ElastaseR +  +  
G-CSFRP +  − LysozymeR +  −  
GM-CSFRP + −  LactoferrinR +  ± 
IL-8RR +  +  GelatinaseR + −  
fMLPRR +  +     
 Normal  PU.1 Null 
Neutrophil Functions  
 Adherence (+PMA)  Present  Present 
 Chemotaxis  
  fMLP  Present  Absent  
  IL-8 Present  Absent  
  Groα  Present  Absent 
 Activation  
  O2− production Present  Absent  
 Phagocytosis  Present  Reduced 
 Bacterial killing  Present  Reduced 
 Normal  PU.1 Null 
Neutrophil Functions  
 Adherence (+PMA)  Present  Present 
 Chemotaxis  
  fMLP  Present  Absent  
  IL-8 Present  Absent  
  Groα  Present  Absent 
 Activation  
  O2− production Present  Absent  
 Phagocytosis  Present  Reduced 
 Bacterial killing  Present  Reduced 

Information in this table reflects data contained within this paper and data previously published in McKercher et al12 and Anderson et al.15 

Abbreviations: R, mRNA; P, protein.

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