Effect of ISIS 2302 on the First Stage (Contact Activation) of the PTT
| First-Stage Incubation (min) . | Control (sec) . | 50 μg/mL ISIS 2302 (sec) . |
|---|---|---|
| 3 | 31.9 ± 0.5 | 49.2 ± 3.1 |
| 10 | 30.1 ± 0.3 | 48.9 ± 0.9 |
| ISIS 2302 added after 3 | 31.6 ± 0.3 | 48.7 ± 0.3 |
| First-Stage Incubation (min) . | Control (sec) . | 50 μg/mL ISIS 2302 (sec) . |
|---|---|---|
| 3 | 31.9 ± 0.5 | 49.2 ± 3.1 |
| 10 | 30.1 ± 0.3 | 48.9 ± 0.9 |
| ISIS 2302 added after 3 | 31.6 ± 0.3 | 48.7 ± 0.3 |
The PTT was performed as described with modification of the first stage as above. Results are expressed as the mean clotting time (seconds) ± SD.