Effect of ISIS 2302 on the Correction of the PTT by Activated Coagulation Factor in Factor-Deficient Plasma
| Plasma . | Factor Added . | Control (sec) . | 50 μg/mL ISIS 2302 (sec) . |
|---|---|---|---|
| Normal | None | 31.9 ± 0.5 | 49.2 ± 3.1 |
| Factor XI deficient | None | 99.9 ± 4.1 | ND |
| 15 nmol/L fXIa | 31.8 ± 0.6 | 50.0 ± 1.2 | |
| Factor IX deficient | None | 102.6 ± 3.6 | ND |
| 20 nmol/L fIXa | 31.9 ± 1.0 | 52.9 ± 1.3 | |
| Factor VIII deficient | None | 82.7 ± 1.0 | ND |
| 0.01 U/mL fVIIIa | 31.1 ± 0.5 | 50.9 ± 0.5 | |
| Factor X deficient | None | 147.2 ± 11.9 | ND |
| 0.2 nmol/L fXa | 30.5 ± 0.1 | 32.1 ± 0.8 | |
| Factor V deficient | None | 183.6 ± 0.1 | ND |
| 0.015 U/mL fVa | 31.1 ± 0.3 | 48.4 ± 0.5 |
| Plasma . | Factor Added . | Control (sec) . | 50 μg/mL ISIS 2302 (sec) . |
|---|---|---|---|
| Normal | None | 31.9 ± 0.5 | 49.2 ± 3.1 |
| Factor XI deficient | None | 99.9 ± 4.1 | ND |
| 15 nmol/L fXIa | 31.8 ± 0.6 | 50.0 ± 1.2 | |
| Factor IX deficient | None | 102.6 ± 3.6 | ND |
| 20 nmol/L fIXa | 31.9 ± 1.0 | 52.9 ± 1.3 | |
| Factor VIII deficient | None | 82.7 ± 1.0 | ND |
| 0.01 U/mL fVIIIa | 31.1 ± 0.5 | 50.9 ± 0.5 | |
| Factor X deficient | None | 147.2 ± 11.9 | ND |
| 0.2 nmol/L fXa | 30.5 ± 0.1 | 32.1 ± 0.8 | |
| Factor V deficient | None | 183.6 ± 0.1 | ND |
| 0.015 U/mL fVa | 31.1 ± 0.3 | 48.4 ± 0.5 |
PTT was performed as described (see Materials and Methods) in normal or factor-deficient plasma in the presence or absence of oligonucleotide. Sufficient activated coagulation factor was added during recalcification to correct the clotting time to control values without oligonucleotide present. Clotting times are expressed as the mean (sec) ± SD.
Abbreviation: ND, not determined.