Distribution of FcγRIIa Genotypes and Allele Frequencies in a Subanalysis of 122 HIT Patients With Thrombocytopenia Only or With Thromboembolic Events During Heparin Administration
| . | n . | FcγRIIa Allele Frequency . | FcγRIIa Genotype* . | . | |||
|---|---|---|---|---|---|---|---|
| R131 . | H131 . | R/R131 . | R/H131 . | H/H131 . | |||
| HIT + TECs† | 68 | 0.59 | 0.41 | 25 (36.8) | 30 (44.1) | 13 (19.1) | P = .036‡ |
| HIT + thrombocytopenia† | 54 | 0.43 | 0.57 | 9 (16.7) | 28 (51.8) | 17 (31.5) | |
| . | n . | FcγRIIa Allele Frequency . | FcγRIIa Genotype* . | . | |||
|---|---|---|---|---|---|---|---|
| R131 . | H131 . | R/R131 . | R/H131 . | H/H131 . | |||
| HIT + TECs† | 68 | 0.59 | 0.41 | 25 (36.8) | 30 (44.1) | 13 (19.1) | P = .036‡ |
| HIT + thrombocytopenia† | 54 | 0.43 | 0.57 | 9 (16.7) | 28 (51.8) | 17 (31.5) | |
*Values are the number of patients with the percentage in parentheses.
HIT + TECs are HIT patients developing thromboembolic events during heparin administration. HIT + thrombocytopenia are HIT patients presenting with thrombocytopenia only.
P values are calculated for FcγRIIa-R/R131, −R/H131, and −H/H131 genotype differences by χ2 test for contingency tables with 2 × 3 fields.