Design of Administration of the Four Treatments
| Treatment . | Placebo . | Aspirin . | Ticlopidine . | Aspirin + Ticlopidine . |
|---|---|---|---|---|
| D1 to D5 | ||||
| 8:00 am | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| Noon | Placebo T | Placebo T | Placebo T | Placebo T |
| 8:00pm | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| D6 to D7 | ||||
| 8:00 am | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| Noon | 2 × Placebo A | 2 × Aspirin | 2 × Placebo A | 2 × Aspirin |
| 8:00 pm | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| D8 | ||||
| 8:00 am | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| Noon | 2 × Placebo A | 2 × Aspirin | 2 × Placebo A | 2 × Aspirin |
| 2:00 pm | Perfusion | Perfusion | Perfusion | Perfusion |
| Treatment . | Placebo . | Aspirin . | Ticlopidine . | Aspirin + Ticlopidine . |
|---|---|---|---|---|
| D1 to D5 | ||||
| 8:00 am | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| Noon | Placebo T | Placebo T | Placebo T | Placebo T |
| 8:00pm | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| D6 to D7 | ||||
| 8:00 am | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| Noon | 2 × Placebo A | 2 × Aspirin | 2 × Placebo A | 2 × Aspirin |
| 8:00 pm | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| D8 | ||||
| 8:00 am | Placebo T | Placebo T | Ticlopidine | Ticlopidine |
| Noon | 2 × Placebo A | 2 × Aspirin | 2 × Placebo A | 2 × Aspirin |
| 2:00 pm | Perfusion | Perfusion | Perfusion | Perfusion |
Ticlopidine, 250 mg/tablet; Aspirin, 162.5 mg/tablet; Placebo T, tablet identical to ticlopidine; Placebo A, tablet identical to aspirin.