Effect of Aspirin and Ticlopidine on Platelet Aggregation
% . | ADP (μmol/L) . | Collagen (μg/mL) . | Arachidonic Acid (mmol/L) . | ||
---|---|---|---|---|---|
2.5 . | 5 . | 3.3 . | 10 . | 1 . | |
Placebo | 36 ± 5 | 49 ± 3 | 59 ± 2 | 60 ± 2 | 49 ± 4 |
Aspirin | 25 ± 3 | 42 ± 2 | 30 ± 2* | 51 ± 2* | 2 ± 1* |
Ticlopidine | 13 ± 2* | 23 ± 4* | 54 ± 3 | 60 ± 2 | 40 ± 5 |
Aspirin + ticlopidine | 12 ± 1* | 20 ± 2* | 16 ± 3* | 34 ± 2* | 1 ± 1* |
% . | ADP (μmol/L) . | Collagen (μg/mL) . | Arachidonic Acid (mmol/L) . | ||
---|---|---|---|---|---|
2.5 . | 5 . | 3.3 . | 10 . | 1 . | |
Placebo | 36 ± 5 | 49 ± 3 | 59 ± 2 | 60 ± 2 | 49 ± 4 |
Aspirin | 25 ± 3 | 42 ± 2 | 30 ± 2* | 51 ± 2* | 2 ± 1* |
Ticlopidine | 13 ± 2* | 23 ± 4* | 54 ± 3 | 60 ± 2 | 40 ± 5 |
Aspirin + ticlopidine | 12 ± 1* | 20 ± 2* | 16 ± 3* | 34 ± 2* | 1 ± 1* |
Results are expressed as % of the maximal amplitude of the platelet aggregation curve.
P < .01 versus placebo.