Effect of Treatment on Activation of Platelets and Coagulation on Collagen-Coated Coverslips
| Collagen . | βTG (μg/L) . | T-AT (μg/L) . | FPA (μg/L) . |
|---|---|---|---|
| Placebo | 166 ± 31 | 4.2 ± 0.5 | 6.1 ± 1.5 |
| Aspirin | 89 ± 133-150 | 5.8 ± 2.3 | 7.0 ± 2.4 |
| Ticlopidine | 97 ± 93-151 | 3.5 ± 0.2 | 4.0 ± 0.8 |
| Aspirin + ticlopidine | 82 ± 93-150 | 3.2 ± 0.2 | 3.4 ± 0.5 |
| Collagen . | βTG (μg/L) . | T-AT (μg/L) . | FPA (μg/L) . |
|---|---|---|---|
| Placebo | 166 ± 31 | 4.2 ± 0.5 | 6.1 ± 1.5 |
| Aspirin | 89 ± 133-150 | 5.8 ± 2.3 | 7.0 ± 2.4 |
| Ticlopidine | 97 ± 93-151 | 3.5 ± 0.2 | 4.0 ± 0.8 |
| Aspirin + ticlopidine | 82 ± 93-150 | 3.2 ± 0.2 | 3.4 ± 0.5 |
Nonanticoagulated human blood was perfused over collagen-coated coverslips for 3 minutes at a shear rate of 2,600 s−1. Markers of activation of platelets (βTG) and coagulation (TAT, FPA) were measured in blood collected at the flow outlet of the chamber between 2.5 and 3 minutes perfusion.
P < .01 versus placebo.
P < .05 versus placebo.