Table 2. Allele Frequencies of CD31... | American Society of Hematology

Table 2.

Allele Frequencies of CD31 Polymorphisms in Japanese Subjects (28 Families, 112 Haploides)

Tentative Name of Allele	Substituted Amino Acids in Each Codon				No.	AF^*	Δ^†
	Exon 3 Codons		Exon 8 Codon	Exon 12 Codon
	80	125	563	670
A	Val	Leu	Ser	Arg	46	0.411	0.133
B	Val	Val	Asn	Gly	39	0.348	0.133
C	Val	Val	Ser	Arg	21	0.188	−0.133
D	Val	Leu	Asn	Gly	6	0.054	−0.133
E	Met	Val	Asn	Gly	0	0

Tentative Name of Allele	Substituted Amino Acids in Each Codon				No.	AF^*	Δ^†
	Exon 3 Codons		Exon 8 Codon	Exon 12 Codon
	80	125	563	670
A	Val	Leu	Ser	Arg	46	0.411	0.133
B	Val	Val	Asn	Gly	39	0.348	0.133
C	Val	Val	Ser	Arg	21	0.188	−0.133
D	Val	Leu	Asn	Gly	6	0.054	−0.133
E	Met	Val	Asn	Gly	0	0

Amino acid substitutions of the five CD31 alleles are shown. Only those alleles observed have been named tentatively in the present study. The allele CD31 E was found in population study, but not in family study.

Allele frequency, calculated by “direct counting method.”

†

Delta value, representing linkage disequilibrium, calculated by formula: Δ(X_iY_j) = AF(X_iY_j) − x_iy_j. Suppose that there are two different mutation domains, codon 80/125 and codon 563/670, and let X_i and Y_j. In the above equation, AF represents the allele frequency, and x_iand y_j represent the mutated amino acid frequencies of X_i and Y_j, respectively.

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