Table 3.

Lymphocyte Subpopulations: Absolute Numbers and Activation Antigen Expression

CD3+ (T Cells)/(109/L)CD4+ (T-Helper)/(109/L)CD8+ (T Cytotoxic)/(109/L)CD19+ (B Cells)/(109/L)CD3−CD16+ NK Cells/(109/L) CD3+HLA-DR+ Activated T Cells† (%)
Normal ranges* 0.77 to 2.67  0.53 to 1.75  0.30 to 1.02  0.06 to 0.65  0.20 to 0.44  <20% 
Patient ID  
 PNH003  1.29  0.39  0.90  0.06 0.14  49.0  
 PNH008  1.86  0.74  1.09  0.06 0.25  8.5  
 PNH012  1.31  0.61  0.64  0.03 0.02  19.0  
 PNH019  1.63  0.99  0.64  0.13 0.13  16.0  
 PNH020  1.02  0.64  0.31  0.07 0.02  1.9  
 PNH022  0.54  0.33  0.20  0.05 0.01  16.0  
 PNH030  1.46  0.86  0.66  0.03 0.16  17.5  
 PNH033  0.53  0.34  0.18  0.01 0.02  5.1  
 PNH034  1.14  0.74  0.38  0.03 0.05  13.3  
 PNH042  0.89  0.48  0.40  0.06 0.08  10.0  
 PNH043  0.78  0.24  0.40  0.02 0.23  8.9  
 PNH047  0.93  0.33  0.56  0.03 0.15  4.0  
 PNH048  0.97  0.51  0.44  0.06 0.15  4.0  
 PNH058  1.40  0.94  0.34  0.05 0.09  4.8  
 PNH061  1.18  0.97  0.21  0.14 0.05  10.0  
 PNH063  0.54  0.27  0.23  0.02 0.18  16.3  
 PNH064  2.61  1.31  1.14  0.19 0.06  2.6  
 PNH072  0.82  0.44  0.44  0.03 0.01  21.9  
 PNH079  0.68  0.42  0.22  0.01 0.01  24.3  
Median value  1.020  0.510  0.40 0.05  0.08  — 
CD3+ (T Cells)/(109/L)CD4+ (T-Helper)/(109/L)CD8+ (T Cytotoxic)/(109/L)CD19+ (B Cells)/(109/L)CD3−CD16+ NK Cells/(109/L) CD3+HLA-DR+ Activated T Cells† (%)
Normal ranges* 0.77 to 2.67  0.53 to 1.75  0.30 to 1.02  0.06 to 0.65  0.20 to 0.44  <20% 
Patient ID  
 PNH003  1.29  0.39  0.90  0.06 0.14  49.0  
 PNH008  1.86  0.74  1.09  0.06 0.25  8.5  
 PNH012  1.31  0.61  0.64  0.03 0.02  19.0  
 PNH019  1.63  0.99  0.64  0.13 0.13  16.0  
 PNH020  1.02  0.64  0.31  0.07 0.02  1.9  
 PNH022  0.54  0.33  0.20  0.05 0.01  16.0  
 PNH030  1.46  0.86  0.66  0.03 0.16  17.5  
 PNH033  0.53  0.34  0.18  0.01 0.02  5.1  
 PNH034  1.14  0.74  0.38  0.03 0.05  13.3  
 PNH042  0.89  0.48  0.40  0.06 0.08  10.0  
 PNH043  0.78  0.24  0.40  0.02 0.23  8.9  
 PNH047  0.93  0.33  0.56  0.03 0.15  4.0  
 PNH048  0.97  0.51  0.44  0.06 0.15  4.0  
 PNH058  1.40  0.94  0.34  0.05 0.09  4.8  
 PNH061  1.18  0.97  0.21  0.14 0.05  10.0  
 PNH063  0.54  0.27  0.23  0.02 0.18  16.3  
 PNH064  2.61  1.31  1.14  0.19 0.06  2.6  
 PNH072  0.82  0.44  0.44  0.03 0.01  21.9  
 PNH079  0.68  0.42  0.22  0.01 0.01  24.3  
Median value  1.020  0.510  0.40 0.05  0.08  — 

Determined by three-color flow cytometry as described in Materials and Methods.

*

Reference ranges derived form a study of 31 adult normal controls.

†

Figure represents the percentage of T cells expressing the HLA-DR determinant.

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