Table 2. Candidate Human Tumor Antigen... | American Society of Hematology

Table 2.

Candidate Human Tumor Antigen (TA) Epitopes Recognized by T Lymphocytes in Malignant Diseases Treatable With Autologous Transplantation

Malignant Disease	TA Candidate	MHC	Epitope	Cytolytic Responding T Cell	Target Cells Expressing Relevant HLA Molecules	Reference
CML	bcr-abl (b3a2 breakpoint)	HLA-A3	HSATGFKQSSK	Normal donor-derived PBMC	Cell line, normal PBMC	Bocchia et al, 1995, 1996^209,228
CML	bcr	HLA-A2	KLSEQESLL FMVELVEGA MLTNSCVKL	Normal donor-derived PBMC	EBV-transformed B cells	Buzyn et al, 1997²¹¹
AML/CML	Proteinase 3	HLA-A2	VLQELNVTV	Normal donor-derived PBMC	Cell line, allogeneic myeloid leukemic cells	Molldrem et al, 1997²³¹
Breast/ovarian cancer	(Her-2/neu)	HLA-A2 HLA-A2 HLA-A2	KIFGSLAFL ELVSEFSRM IISAVVGIL	Autologous CTL clones Autologous CTL clones Autologous CTL	Allogeneic cell lines Allogeneic cell lines	Fisk et al, 1995²²⁹ Fisk et al, 1995²²⁹ Peoples et al, 1995²³² Linehan et al, 1995²³³
Breast/ovarian cancer	MUC-1	HLA-A11	STAPPAHGV	Autologous CTL	Allogeneic cell lines	Doménech et al, 1995²³⁴

Malignant Disease	TA Candidate	MHC	Epitope	Cytolytic Responding T Cell	Target Cells Expressing Relevant HLA Molecules	Reference
CML	bcr-abl (b3a2 breakpoint)	HLA-A3	HSATGFKQSSK	Normal donor-derived PBMC	Cell line, normal PBMC	Bocchia et al, 1995, 1996^209,228
CML	bcr	HLA-A2	KLSEQESLL FMVELVEGA MLTNSCVKL	Normal donor-derived PBMC	EBV-transformed B cells	Buzyn et al, 1997²¹¹
AML/CML	Proteinase 3	HLA-A2	VLQELNVTV	Normal donor-derived PBMC	Cell line, allogeneic myeloid leukemic cells	Molldrem et al, 1997²³¹
Breast/ovarian cancer	(Her-2/neu)	HLA-A2 HLA-A2 HLA-A2	KIFGSLAFL ELVSEFSRM IISAVVGIL	Autologous CTL clones Autologous CTL clones Autologous CTL	Allogeneic cell lines Allogeneic cell lines	Fisk et al, 1995²²⁹ Fisk et al, 1995²²⁹ Peoples et al, 1995²³² Linehan et al, 1995²³³
Breast/ovarian cancer	MUC-1	HLA-A11	STAPPAHGV	Autologous CTL	Allogeneic cell lines	Doménech et al, 1995²³⁴