Hematologic Recovery After Chemotherapy and Clinical Outcome by Treatment Assignment
| Endpoint . | Median Days (IQR)* . | ||
|---|---|---|---|
| G-CSF Group . | Placebo Group . | P . | |
| Course I | |||
| Recovery to ANC >1,000/μL | 16 (15-18) | 22 (19-29) | <.001 |
| Duration of neutropenia | 13 (10-16) | 20 (15-27) | <.001 |
| Recovery to platelets >50,000/μL | 16 (14-20) | 19 (15-23) | .003 |
| Duration of thrombocytopenia | 14 (9-17) | 17 (11-22) | .008 |
| Fever >38.5°C | 3 (1-5) | 3 (2-7) | .44 |
| Hospitalization | 22 (18-29) | 28 (22-33) | .02 |
| Course IIA | |||
| Recovery to ANC >1,000/μL | 20 (6-25) | 29 (22-31) | <.001 |
| Duration of neutropenia | 5 (0-12) | 13 (6-18) | <.001 |
| Recovery to platelets >50,000/μL | 20 (17-22) | 20 (18-22) | .53 |
| Duration of thrombocytopenia | 7 (1-9) | 5 (2-7) | .21 |
| Fever >38.5°C | 0 (0-5) | 0 (0-3) | .78 |
| Hospitalization | 7 (0-17) | 3 (0-14) | .32 |
| Course IIB | |||
| Recovery to ANC >1,000/μL | 25 (15-32) | 31 (27-39) | <.001 |
| Duration of neutropenia | 11 (4-17) | 14 (10-25) | .001 |
| Recovery to platelets >50,000/μL | 24 (21-31) | 22 (0-28) | .03 |
| Duration of thrombocytopenia | 10 (7-20) | 7 (0-15) | .02 |
| Fever >38.5°C | 1 (0-3) | 1 (0-6) | .26 |
| Hospitalization | 4 (0-21) | 2 (0-15) | .17 |
| Course III | |||
| Interval on study to the beginning of Course III | 106 (96-117) | 108 (103-117) | .60 |
| Endpoint . | Median Days (IQR)* . | ||
|---|---|---|---|
| G-CSF Group . | Placebo Group . | P . | |
| Course I | |||
| Recovery to ANC >1,000/μL | 16 (15-18) | 22 (19-29) | <.001 |
| Duration of neutropenia | 13 (10-16) | 20 (15-27) | <.001 |
| Recovery to platelets >50,000/μL | 16 (14-20) | 19 (15-23) | .003 |
| Duration of thrombocytopenia | 14 (9-17) | 17 (11-22) | .008 |
| Fever >38.5°C | 3 (1-5) | 3 (2-7) | .44 |
| Hospitalization | 22 (18-29) | 28 (22-33) | .02 |
| Course IIA | |||
| Recovery to ANC >1,000/μL | 20 (6-25) | 29 (22-31) | <.001 |
| Duration of neutropenia | 5 (0-12) | 13 (6-18) | <.001 |
| Recovery to platelets >50,000/μL | 20 (17-22) | 20 (18-22) | .53 |
| Duration of thrombocytopenia | 7 (1-9) | 5 (2-7) | .21 |
| Fever >38.5°C | 0 (0-5) | 0 (0-3) | .78 |
| Hospitalization | 7 (0-17) | 3 (0-14) | .32 |
| Course IIB | |||
| Recovery to ANC >1,000/μL | 25 (15-32) | 31 (27-39) | <.001 |
| Duration of neutropenia | 11 (4-17) | 14 (10-25) | .001 |
| Recovery to platelets >50,000/μL | 24 (21-31) | 22 (0-28) | .03 |
| Duration of thrombocytopenia | 10 (7-20) | 7 (0-15) | .02 |
| Fever >38.5°C | 1 (0-3) | 1 (0-6) | .26 |
| Hospitalization | 4 (0-21) | 2 (0-15) | .17 |
| Course III | |||
| Interval on study to the beginning of Course III | 106 (96-117) | 108 (103-117) | .60 |
*25th to 75th percentiles.