Effect of IL-10 on EPO-Dependent BFU-E Growth in Normal Individuals
| Patient No. . | BFU-E ± SD/Dish . | Percent of Inhibition . | |
|---|---|---|---|
| Control . | +IL-10 . | ||
| 1 | 13.0 ± 5.0 | 8.3 ± 2.1 | 36 |
| 2 | 33.0 ± 2.7 | 13.7 ± 10.1 | 58 |
| 3 | 36.0 ± 4.4 | 23.7 ± 5.0 | 34 |
| 4 | 30.3 ± 2.1 | 19.0 ± 3.0 | 37 |
| 5 | 53.7 ± 3.5 | 22.7 ± 2.5 | 58 |
| Patient No. . | BFU-E ± SD/Dish . | Percent of Inhibition . | |
|---|---|---|---|
| Control . | +IL-10 . | ||
| 1 | 13.0 ± 5.0 | 8.3 ± 2.1 | 36 |
| 2 | 33.0 ± 2.7 | 13.7 ± 10.1 | 58 |
| 3 | 36.0 ± 4.4 | 23.7 ± 5.0 | 34 |
| 4 | 30.3 ± 2.1 | 19.0 ± 3.0 | 37 |
| 5 | 53.7 ± 3.5 | 22.7 ± 2.5 | 58 |
A total of 105 PBMNC/dish from 5 healthy volunteers were cultured in the presence of 2 U/mL EPO as described in the Materials and Methods with or without 10 ng/mL IL-10. Colony growth was assessed after 14 days. Results represent mean values ± SD from triplicates.