Effect of GCV on Blood Cell Counts in MIIb-tk Mice
| . | Platelets . | Erythrocytes . | Leukocytes . |
|---|---|---|---|
| Last stage of GCV treatment | 91.4 ± 3.7 | 71.1 ± 13.2 | 82.2 ± 6.9 |
| 48 h to 4 d into recovery | 91.2 ± 4.5 | 52.4 ± 20 | 48.3 ± 7.3 |
| 6 to 8 d into recovery | 62 ± 9.8 | 48 ± 1.2 | 34.6 ± 8.2 |
| 15 to 20 d into recovery | 35.7 ± 2.5 | 21.5 ± 7.7 | 22 ± 0 |
| . | Platelets . | Erythrocytes . | Leukocytes . |
|---|---|---|---|
| Last stage of GCV treatment | 91.4 ± 3.7 | 71.1 ± 13.2 | 82.2 ± 6.9 |
| 48 h to 4 d into recovery | 91.2 ± 4.5 | 52.4 ± 20 | 48.3 ± 7.3 |
| 6 to 8 d into recovery | 62 ± 9.8 | 48 ± 1.2 | 34.6 ± 8.2 |
| 15 to 20 d into recovery | 35.7 ± 2.5 | 21.5 ± 7.7 | 22 ± 0 |
Results represent the percentage decrease in blood cell counts (±SD) after 7 days of GCV administration (0.1 mg/d/g body weight), during the early stage of recovery (48 hours to 4 days after discontinuing GCV), and during the late phase of recovery (6 to 8 days and 15 to 20 days after GCV withdrawal).