Summary of PTEN Alterations in Lymphoid Neoplasms
| Case No./ Cell Line . | Type . | Exon/Intron . | Codon . | Alteration . | Predicted Effect . |
|---|---|---|---|---|---|
| CEM | LBL | Exon 2-5 | Deletion | Loss of phosphatase domain | |
| Jurkat | LBL | Exon 7 | 234 | 2-bp deletion and 9-bp insertion | Stop codons downstream |
| Exon 7 | 246 | 39-bp insertion | Stop codon at 247 | ||
| SUDHL10 | LBCL | Exon 3 | 68 | TAC to CAC | Tyr to His |
| Exon 5 | 162 | GAC to CAC | Asp to His | ||
| PA682PB | BL | Exon 6 | 166 | GTA to CTA | Val to Leu |
| Raji | BL | Intron 7 | 38-bp deletion | Unknown; polymorphism? | |
| Jim3 | Myeloma | Intron 7 | 3-bp deletion | Unknown; polymorphism? | |
| Case 1706 | LBCL | Intron 7 | 2-bp deletion | Unknown; polymorphism? | |
| Case 1517 | LBCL | Intron 7 | 38-bp deletion | Unknown; polymorphism? | |
| Case 2734 | LBCL | Exon 1 | A to G; 12-bp before initiation codon | Unknown | |
| Exon 1 | 16 | TAT to TGT | Tyr to Cys |
| Case No./ Cell Line . | Type . | Exon/Intron . | Codon . | Alteration . | Predicted Effect . |
|---|---|---|---|---|---|
| CEM | LBL | Exon 2-5 | Deletion | Loss of phosphatase domain | |
| Jurkat | LBL | Exon 7 | 234 | 2-bp deletion and 9-bp insertion | Stop codons downstream |
| Exon 7 | 246 | 39-bp insertion | Stop codon at 247 | ||
| SUDHL10 | LBCL | Exon 3 | 68 | TAC to CAC | Tyr to His |
| Exon 5 | 162 | GAC to CAC | Asp to His | ||
| PA682PB | BL | Exon 6 | 166 | GTA to CTA | Val to Leu |
| Raji | BL | Intron 7 | 38-bp deletion | Unknown; polymorphism? | |
| Jim3 | Myeloma | Intron 7 | 3-bp deletion | Unknown; polymorphism? | |
| Case 1706 | LBCL | Intron 7 | 2-bp deletion | Unknown; polymorphism? | |
| Case 1517 | LBCL | Intron 7 | 38-bp deletion | Unknown; polymorphism? | |
| Case 2734 | LBCL | Exon 1 | A to G; 12-bp before initiation codon | Unknown | |
| Exon 1 | 16 | TAT to TGT | Tyr to Cys |