Table 2. Class Switching in Follicular... | American Society of Hematology

Table 2.

Class Switching in Follicular Lymphoma

Case	Ig Expression		Allele 1	Allele 2 t(14;18)
Case	IgL	IgH	Allele 1	Allele 2 t(14;18)
FL1	κ	M	—	γ1
FL2	λ	M	—	—
FL3	κ	MD	—	γ1
FL4	κ	M(D)	—	α1
FL5	κ	M	ds rear	γ1
FL6	κ	MD	ds rear	γ1
FL7	κ	M(D)	ds rear	γ4
FL8	κ	M	ds rear	—
FL9	κ	M(D)	ds rear	γ1
FL10	λ	M(D)	ds rear\γ4?	γ4
FL11	κ	M	ds rear	γ1
FL12	λ	MD	ds rear	γ1
FL13	(κ)	M	ds rear	α1
FL14	λ	—	ds rear	γ2
FL15	κ	G2	γ^*	γ1
FL16	λ	G1	γ1	γ1 + ds rear
FL17	κ	G1	γ1	γ2
FL18	λ	G2	γ^*	γ1
FL19	κ	G	γ2	γ1
FL20	κ	G1	γ1 + ds rear	α1
FL21	λ	G4	γ^*	ds rear
FL22	—	—	γ1	γ1
FL23	(κ)	—	γ^*	γ1

Case	Ig Expression		Allele 1	Allele 2 t(14;18)
Case	IgL	IgH	Allele 1	Allele 2 t(14;18)
FL1	κ	M	—	γ1
FL2	λ	M	—	—
FL3	κ	MD	—	γ1
FL4	κ	M(D)	—	α1
FL5	κ	M	ds rear	γ1
FL6	κ	MD	ds rear	γ1
FL7	κ	M(D)	ds rear	γ4
FL8	κ	M	ds rear	—
FL9	κ	M(D)	ds rear	γ1
FL10	λ	M(D)	ds rear\γ4?	γ4
FL11	κ	M	ds rear	γ1
FL12	λ	MD	ds rear	γ1
FL13	(κ)	M	ds rear	α1
FL14	λ	—	ds rear	γ2
FL15	κ	G2	γ^*	γ1
FL16	λ	G1	γ1	γ1 + ds rear
FL17	κ	G1	γ1	γ2
FL18	λ	G2	γ^*	γ1
FL19	κ	G	γ2	γ1
FL20	κ	G1	γ1 + ds rear	α1
FL21	λ	G4	γ^*	ds rear
FL22	—	—	γ1	γ1
FL23	(κ)	—	γ^*	γ1

The second column shows immunoglobulin class and subclass expression as determined by immunofluorescence. Brackets were used to indicate weak expression. In case FL19, IgG subclass expression could not be determined. In the right two columns class-switch deletions on nontranslocated (allele 1) and translocated (allele 2) tumor alleles are indicated. In FL10 two nontranslocated alleles were identified, as shown. The question mark is explained in Results. Downstream rearrangements are indicated by ds rear. In cases FL5-14 these alleles had retained the Cμ-Cδ region, in FL16 and FL20 the downstream rearrangement was present together with an apparently normal γ1 switch.

The switch target gene could not be identified due to polymorphisms.

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