Effects of Dexamethasone in 43 Episodes of ACS Occurring in 38 Children With SCD
| . | Dexamethasone (n = 22) . | Placebo (n = 21) . | P Value . |
|---|---|---|---|
| Length of hospitalization (h) | |||
| Mean | 47 | 80 | .005 |
| Range | 18-87 | 34-245 | |
| SD | 16 | 50 | |
| Duration of oxygen therapy (h) | |||
| Mean | 30 | 60 | .004 |
| Range | 11-83 | 9-162 | |
| SD | 18 | 43 | |
| Duration of opioid therapy (h) | |||
| Mean | 19 | 76 | <.001 |
| Range | 2-37 | 37-123 | |
| SD | 14 | 31 | |
| No. of administered opioid doses | <.001 | ||
| Mean | 2.46 | 20.2 | |
| Range | 1-5 | 2-53 | |
| SD | 1.37 | 15.6 | |
| Persistent fever | 1 (4.5%) | 14 (67%) | <.001 |
| Occurrence of clinical deterioration | 0 | 8 (38%) | <.001 |
| Blood transfusion requirements | 2 (9%) | 10 (47%) | .013 |
| Readmission within 72 hours after discharge | 6 (27%) | 1 (4.7%) | .095 |
| Readmission with ACS within 72 hours after discharge | 1 (4.5%) | 0 | 1.000 |
| . | Dexamethasone (n = 22) . | Placebo (n = 21) . | P Value . |
|---|---|---|---|
| Length of hospitalization (h) | |||
| Mean | 47 | 80 | .005 |
| Range | 18-87 | 34-245 | |
| SD | 16 | 50 | |
| Duration of oxygen therapy (h) | |||
| Mean | 30 | 60 | .004 |
| Range | 11-83 | 9-162 | |
| SD | 18 | 43 | |
| Duration of opioid therapy (h) | |||
| Mean | 19 | 76 | <.001 |
| Range | 2-37 | 37-123 | |
| SD | 14 | 31 | |
| No. of administered opioid doses | <.001 | ||
| Mean | 2.46 | 20.2 | |
| Range | 1-5 | 2-53 | |
| SD | 1.37 | 15.6 | |
| Persistent fever | 1 (4.5%) | 14 (67%) | <.001 |
| Occurrence of clinical deterioration | 0 | 8 (38%) | <.001 |
| Blood transfusion requirements | 2 (9%) | 10 (47%) | .013 |
| Readmission within 72 hours after discharge | 6 (27%) | 1 (4.7%) | .095 |
| Readmission with ACS within 72 hours after discharge | 1 (4.5%) | 0 | 1.000 |