Pharmacokinetic Parameters After Intravenous and Subcutaneous Administration of Sargramostim in Healthy Adult Males
| Pharmacokinetic Parameter . | Sargramostim at 250 μg/m2 . | |
|---|---|---|
| IV . | SC . | |
| Cmax (ng/mL) | 5.0-5.4 | 1.5 |
| AUC (ng/mL · min) | 640-677 | 501-549 |
| Clearance (mL/min/m2) | 420-431 | 529-549 |
| t1/2β (min) | 60 | 162 |
| Pharmacokinetic Parameter . | Sargramostim at 250 μg/m2 . | |
|---|---|---|
| IV . | SC . | |
| Cmax (ng/mL) | 5.0-5.4 | 1.5 |
| AUC (ng/mL · min) | 640-677 | 501-549 |
| Clearance (mL/min/m2) | 420-431 | 529-549 |
| t1/2β (min) | 60 | 162 |
Abbreviations: Cmax, peak plasma concentration; AUC, area under the concentration-versus-time curve; t1/2β, terminal elimination half-life; IV, intravenous; SC, subcutaneous.