Sensitivity of Myeloid Progenitors to DT388-GM-CSF In Vitro
| Patient . | Disease . | No. Colonies/ 2 × 105Cells . | IC50 (pmol/L) . | Maximal Log Cell Kill . |
|---|---|---|---|---|
| AJ | JMML | 790 | 160 | 1.3 |
| NL | JMML | 560 | 20 | 1.4 |
| HA | JMML | 2700 | 20 | 1.4 |
| CF | JMML | 26 | 10 | 1.4 |
| PR | JMML | 11 | 10 | 1.1 |
| MS | JMML | 90 | 4 | 0.8 |
| CB | JMML | 900 | 80 | 0.7 |
| G | CMML | 80 | 5 | 1.3 |
| CL | CMML | 210 | 60 | 1.5 |
| RS | CMML | 560 | 1500 | 0.7 |
| WS | CMML | 680 | 1 | 1.8 |
| AR | CMML | 81 | 3 | 1.9 |
| JT | CMML | 480 | 20 | 1.0 |
| CT | CMML | ND | ND | ND |
| LS | CMML | 31 | 40,000 | 0.3 |
| RB | CMML | 110 | >40,000 | 0.3 |
| WB | CMML | 130 | 8 | 2.2 |
| FB | CMML | 280 | 600 | 2.4 |
| GN | CMML | 17 | 20 | 1.3 |
| GW | CMML | 220 | 80 | 2.4 |
| RM | CMML | 120 | 70 | 2.2 |
| EB | CMML | 41 | 70 | 1.5 |
| KP | CMML | 20 | >40,000 | <0.3 |
| SB | CMML | 2600 | >40,000 | <0.3 |
| PP | CMML | 32 | >40,000 | <0.3 |
| DJ | CMML | 130 | 500 | 2.2 |
| ED | CMML | 3500 | >40,000 | <0.3 |
| LP | CMML | 120 | >40,000 | <0.3 |
| CAD25* | Normal | 200 | 1000 | 0.9 |
| CAD* | Normal | 2100 | 40,000 | 0.3 |
| CAD24D* | Normal | 2200 | 4000 | 0.6 |
| U11802 | Normal | 190 | >40,000 | <0.3 |
| U11811 | Normal | 260 | 40,000 | <0.3 |
| U11454 | Normal | 27 | 40,000 | <0.3 |
| Patient . | Disease . | No. Colonies/ 2 × 105Cells . | IC50 (pmol/L) . | Maximal Log Cell Kill . |
|---|---|---|---|---|
| AJ | JMML | 790 | 160 | 1.3 |
| NL | JMML | 560 | 20 | 1.4 |
| HA | JMML | 2700 | 20 | 1.4 |
| CF | JMML | 26 | 10 | 1.4 |
| PR | JMML | 11 | 10 | 1.1 |
| MS | JMML | 90 | 4 | 0.8 |
| CB | JMML | 900 | 80 | 0.7 |
| G | CMML | 80 | 5 | 1.3 |
| CL | CMML | 210 | 60 | 1.5 |
| RS | CMML | 560 | 1500 | 0.7 |
| WS | CMML | 680 | 1 | 1.8 |
| AR | CMML | 81 | 3 | 1.9 |
| JT | CMML | 480 | 20 | 1.0 |
| CT | CMML | ND | ND | ND |
| LS | CMML | 31 | 40,000 | 0.3 |
| RB | CMML | 110 | >40,000 | 0.3 |
| WB | CMML | 130 | 8 | 2.2 |
| FB | CMML | 280 | 600 | 2.4 |
| GN | CMML | 17 | 20 | 1.3 |
| GW | CMML | 220 | 80 | 2.4 |
| RM | CMML | 120 | 70 | 2.2 |
| EB | CMML | 41 | 70 | 1.5 |
| KP | CMML | 20 | >40,000 | <0.3 |
| SB | CMML | 2600 | >40,000 | <0.3 |
| PP | CMML | 32 | >40,000 | <0.3 |
| DJ | CMML | 130 | 500 | 2.2 |
| ED | CMML | 3500 | >40,000 | <0.3 |
| LP | CMML | 120 | >40,000 | <0.3 |
| CAD25* | Normal | 200 | 1000 | 0.9 |
| CAD* | Normal | 2100 | 40,000 | 0.3 |
| CAD24D* | Normal | 2200 | 4000 | 0.6 |
| U11802 | Normal | 190 | >40,000 | <0.3 |
| U11811 | Normal | 260 | 40,000 | <0.3 |
| U11454 | Normal | 27 | 40,000 | <0.3 |
For treatment conditions and assay details, see Materials and Methods.
Experiments performed with purified CD34+ cells from these samples.