Table 3.

Pharmacokinetics of BTI-322

t1/2 (h) Cmax (ng/mL) Vd (L)Vd (L/kg) Cl (L/h)
All patients  
 Dose 1 9.1 (1.3)3-150 2,549 (291)  3.97 (0.96) 0.05 (0.012)  0.36  
 Dose 4  11.2 (1.8) 2,986 (306)  2.88 (0.33)  0.03 (0.003)  0.22  
No gut GVHD (n = 4)  
 Dose 1  10.4 (2.8)  2,709 (465) 3.13 (0.63)  0.04 (0.006)  0.24  
 Dose 4 11.8 (1.9)  3,118 (489)  2.75 (0.41)  0.03 (0.005) 0.18  
With gut GVHD (n = 6)  
 Dose 1  8.3 (1.3) 2,442 (402)  4.53 (1.56)  0.05 (0.020)  0.44  
 Dose 4  10.7 (2.9)  2,898 (426)  2.96 (0.51)  0.03 (0.004) 0.24 
t1/2 (h) Cmax (ng/mL) Vd (L)Vd (L/kg) Cl (L/h)
All patients  
 Dose 1 9.1 (1.3)3-150 2,549 (291)  3.97 (0.96) 0.05 (0.012)  0.36  
 Dose 4  11.2 (1.8) 2,986 (306)  2.88 (0.33)  0.03 (0.003)  0.22  
No gut GVHD (n = 4)  
 Dose 1  10.4 (2.8)  2,709 (465) 3.13 (0.63)  0.04 (0.006)  0.24  
 Dose 4 11.8 (1.9)  3,118 (489)  2.75 (0.41)  0.03 (0.005) 0.18  
With gut GVHD (n = 6)  
 Dose 1  8.3 (1.3) 2,442 (402)  4.53 (1.56)  0.05 (0.020)  0.44  
 Dose 4  10.7 (2.9)  2,898 (426)  2.96 (0.51)  0.03 (0.004) 0.24 
F3-150

Mean (SE).

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