Table 3. Effects of G-CSF on Bacterial... | American Society of Hematology

Table 3.

Effects of G-CSF on Bacterial Products, Cytokines, and Survival Administered Before Induction of Sepsis in Animals

Animal	Sepsis Model	Effects of G-CSF on					Reference
Animal	Sepsis Model	Endotoxin Levels	Bacterial Counts	TNF-α	Interleukins	Survival	Reference
Mouse/rat	LPS-induced septic shock			↓		↑	108
Canine	Intraperitoneal E coli clot	↓	↓	↓		↑	141
Rat	Fecal inoculum			↓		↑	142
Porcine	Pseudomonas sepsis	↓		↓		↑	143
Rat	Cecal perforation	↓	↓	↓		↑	105
Mouse	Superantigen mediated shock				↓ IL-2	↑	140
Mouse	LPS-induced septic shock			—	↓ IL-1β	↑	144
					↓ IFN-γ
					↓ IL-10

Animal	Sepsis Model	Effects of G-CSF on					Reference
Animal	Sepsis Model	Endotoxin Levels	Bacterial Counts	TNF-α	Interleukins	Survival	Reference
Mouse/rat	LPS-induced septic shock			↓		↑	108
Canine	Intraperitoneal E coli clot	↓	↓	↓		↑	141
Rat	Fecal inoculum			↓		↑	142
Porcine	Pseudomonas sepsis	↓		↓		↑	143
Rat	Cecal perforation	↓	↓	↓		↑	105
Mouse	Superantigen mediated shock				↓ IL-2	↑	140
Mouse	LPS-induced septic shock			—	↓ IL-1β	↑	144
					↓ IFN-γ
					↓ IL-10

Abbreviations: ↑, increase; −, no effect; ↓, decrease.