Table 5. P-gp Expression and Function in... | American Society of Hematology

Table 5.

P-gp Expression and Function in Leukemic Blasts From 19 Patients in Whom P-gp Expression, Rhodamine Accumulation, and Inhibition of Rhodamine Efflux by PSC 833 Were Measured

Patient No.	% P-gp– Positive Cells^5-150	% Mean Channel Shift^5-151	% CD34Positive Cells	Response
PSC 833 Inhibitable P-gp Function
3	53	30	98	F
8	40	34	97	F
9	54	47	94	PR
16	35	40	97	CR
19	27	43	45	F
20	45	29	95	CR
22	77	47	16	F
34	96	90	88	F

PSC 833 Noninhibitable P-gp Function
2	6	42	82	F
10	16	33	4	F
18	1	46	86	F
21	17	69	51	F
29	40	35	25	F
30	20	70	85	F
39	37	38	27	F

No P-gp Function
1	2	0	2	PR
4	7	0	6	CR
5	13	0	28	F
7	3	0	73	F

Patient No.	% P-gp– Positive Cells^5-150	% Mean Channel Shift^5-151	% CD34Positive Cells	Response
PSC 833 Inhibitable P-gp Function
3	53	30	98	F
8	40	34	97	F
9	54	47	94	PR
16	35	40	97	CR
19	27	43	45	F
20	45	29	95	CR
22	77	47	16	F
34	96	90	88	F

PSC 833 Noninhibitable P-gp Function
2	6	42	82	F
10	16	33	4	F
18	1	46	86	F
21	17	69	51	F
29	40	35	25	F
30	20	70	85	F
39	37	38	27	F

No P-gp Function
1	2	0	2	PR
4	7	0	6	CR
5	13	0	28	F
7	3	0	73	F

Abbreviation: F, failure.

F5-150

% 4E3 positive blast cells.

F5-151

The relative rhodamine-123 mean fluorescence channel shift from baseline (maximal dye uptake and retention) that occurred during a 1-hour incubation of cells at 37°C (to induce dye efflux) was expressed as percent of maximal dye retention (100%).

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